AIMC Topic: Prospective Studies

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Circulating proteins and metabolites panel for noninvasive preoperative diagnosis of epithelial ovarian cancer.

BMC medicine
BACKGROUND: Existing biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker candidates fo...

Development and validation of a predictive model for new HIV infection screening among persons 15 years and above in primary healthcare settings in Kenya: a study protocol.

BMJ health & care informatics
INTRODUCTION: This study seeks to determine incidence, comorbidities and drivers for new HIV infections to develop, test and validate a risk prediction model for screening for new cases of HIV.

Predictive model integrating deep learning and clinical features based on ultrasound imaging data for surgical intervention in intussusception in children younger than 8 months.

BMJ open
OBJECTIVES: The objective of this study was to identify risk factors for enema reduction failure and to establish a combined model that integrates deep learning (DL) features and clinical features for predicting surgical intervention in intussuscepti...

AI-Based EMG Reporting: A Randomized Controlled Trial.

Journal of neurology
BACKGROUND AND OBJECTIVES: Accurate interpretation of electrodiagnostic (EDX) studies is essential for the diagnosis and management of neuromuscular disorders. Artificial intelligence (AI) based tools may improve consistency and quality of EDX report...

Integrating miRNA profiling and machine learning for improved prostate cancer diagnosis.

Scientific reports
Prostate cancer (PCa) diagnosis remains challenging due to overlapping clinical features with benign prostatic hyperplasia (BPH) and limitations of existing diagnostic tools like PSA tests, which yield high false-positive rates. This study investigat...

Application of deep learning reconstruction at prone position chest scanning of early interstitial lung disease.

BMC medical imaging
AIM: Timely intervention of interstitial lung disease (ILD) was promising for attenuating the lung function decline and improving clinical outcomes. The prone position HRCT is essential for early diagnosis of ILD, but limited by its high radiation ex...

Plasma interleukin-22 concentration and disease activity in inflammatory bowel disease.

Scientific reports
The relationship between interleukin-22 and clinical characteristics of patients with inflammatory bowel disease is uncertain. We sought to determine whether plasma interleukin-22 concentrations are associated with disease activity in a large populat...

Urinary Complement proteome strongly linked to diabetic kidney disease progression.

Nature communications
Diabetic kidney disease (DKD) progression is not well understood. Using high-throughput proteomics, biostatistical, pathway and machine learning tools, we examine the urinary Complement proteome in two prospective cohorts with type 1 or 2 diabetes an...