AIMC Topic: Rats
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A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study.
Journal of food and drug analysis
Aug 14, 2018
Combinations of new antidepressants like duloxetine and second-generation antipsychotics like quetiapine are used in clinical treatment of major depressive disorder, as well as in forensic toxicology scenarios. The drug-drug interaction (DDI) between...
Determination of Optimal Heart Rate Variability Features Based on SVM-Recursive Feature Elimination for Cumulative Stress Monitoring Using ECG Sensor.
Sensors (Basel, Switzerland)
Jul 23, 2018
Routine stress monitoring in daily life can predict potentially serious health impacts. Effective stress monitoring in medical and healthcare fields is dependent upon accurate determination of stress-related features. In this study, we determined the...
Automated detection of electroencephalography artifacts in human, rodent and canine subjects using machine learning.
Journal of neuroscience methods
Jun 23, 2018
BACKGROUND: Electroencephalography (EEG) invariably contains extra-cranial artifacts that are commonly dealt with based on qualitative and subjective criteria. Failure to account for EEG artifacts compromises data interpretation.
Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism.
Alcoholism, clinical and experimental research
Jun 13, 2018
BACKGROUND: A statistical pipeline was developed and used for determining candidate genes and candidate gene coexpression networks involved in 2 alcohol (i.e., ethanol [EtOH]) metabolism phenotypes, namely alcohol clearance and acetate area under the...
Expanding the horizons of microRNA bioinformatics.
RNA (New York, N.Y.)
Jun 5, 2018
MicroRNA regulation of key biological and developmental pathways is a rapidly expanding area of research, accompanied by vast amounts of experimental data. This data, however, is not widely available in bioinformatic resources, making it difficult fo...
Assessing functional connectivity across 3D tissue engineered axonal tracts using calcium fluorescence imaging.
Journal of neural engineering
Jun 1, 2018
OBJECTIVE: Micro-tissue engineered neural networks (micro-TENNs) are anatomically-inspired constructs designed to structurally and functionally emulate white matter pathways in the brain. These 3D neural networks feature long axonal tracts spanning d...
How Much Does Movement and Location Encoding Impact Prefrontal Cortex Activity? An Algorithmic Decoding Approach in Freely Moving Rats.
eNeuro
Apr 27, 2018
Specialized brain structures encode spatial locations and movements, yet there is growing evidence that this information is also represented in the rodent medial prefrontal cortex (mPFC). Disambiguating such information from the encoding of other typ...
Using machine learning and quantum chemistry descriptors to predict the toxicity of ionic liquids.
Journal of hazardous materials
Mar 15, 2018
Large-scale application of ionic liquids (ILs) hinges on the advancement of designable and eco-friendly nature. Research of the potential toxicity of ILs towards different organisms and trophic levels is insufficient. Quantitative structure-activity ...
Disease Ontology: improving and unifying disease annotations across species.
Disease models & mechanisms
Mar 12, 2018
Model organisms are vital to uncovering the mechanisms of human disease and developing new therapeutic tools. Researchers collecting and integrating relevant model organism and/or human data often apply disparate terminologies (vocabularies and ontol...
Brain-specific functional relationship networks inform autism spectrum disorder gene prediction.
Translational psychiatry
Mar 6, 2018
Autism spectrum disorder (ASD) is a neuropsychiatric disorder with strong evidence of genetic contribution, and increased research efforts have resulted in an ever-growing list of ASD candidate genes. However, only a fraction of the hundreds of nomin...
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