AIMC Topic: Rats

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ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...

Toxicological evaluation of Artocarpus lacucha ethyl acetate extract: in vitro and in vivo assessment.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Artocarpus lacucha Buch. -Ham. (syn. Artocarpus lakoocha) (A. lacucha), is a tropical fruit tree and a member of the Moraceae family. Fruit, bark, foliage, and roots of A. lacucha are broadly utilized in folklore medic...

The efficacy and toxicity equilibrium of emodin for liver injury: A bidirectional meta-analysis and machine learning.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Emodin, a hepatoprotective agent derived from various herbs, exhibits dual effects on liver injury, necessitating further investigation into its therapeutic and toxic properties. Traditional meta-analyses lack predictive capability for do...

Neural models for detection and classification of brain states and transitions.

Communications biology
Exploring natural or pharmacologically induced brain dynamics, such as sleep, wakefulness, or anesthesia, provides rich functional models for studying brain states. These models allow detailed examination of unique spatiotemporal neural activity patt...

Therapeutic effect and concomitant toxicity of hydrargyrum chloratum compositum on chronic difficult-to-heal wounds in rats.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Hydrargyrum chloratum compositum(Hcc) is a traditional Chinese medicine for external use, with the efficacy of 'transforming corrosion and pulling out toxins, removing corrosion and regenerating muscles'. The main comp...

Safety assessment of the ethanolic extract of Siparuna guianensis: Cell viability, molecular risk predictions and toxicity risk for acute and sub-chronic oral ingestion.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: The species Siparuna guianensis Aublet (family Siparunaceae) is traditionally used by indigenous peoples and riverine communities in Central and South America to treat migraines, flu, respiratory diseases, fever, pain,...

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii.

Journal of applied toxicology : JAT
Serendipity Berry Sweet Protein (sweelin) is a novel hyper-sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI-CPD) to improve the stability and sensory profile of the protein found in serendipity berry ...

Comparative Assessment of Manual Segmentation of Cerebral Infarction Lesions in Experimental Animals Based on Magnetic Resonance Imaging Using Artificial Intelligence.

Bulletin of experimental biology and medicine
The aim of this study was to evaluate the quality of manual segmentation of cerebral infarction lesions in experimental animals with modeled brain infarct based on magnetic resonance imaging compared to an automated artificial intelligence approach. ...

Deciphering the Pharmacological Potential of Kouqiangjie Formula for the Treatment of Diabetic Periodontitis Based on Network Pharmacology, Machine Learning, Molecular Dynamics, and Animal Experiments.

Drug design, development and therapy
BACKGROUND: Periodontitis (PD) and type 2 diabetes mellitus (T2DM) represent interlinked global health burdens, commonly causing significant clinical complications when coincident. Therefore, managing both conditions (T2DM with periodontitis, DP) sim...