AIMC Topic: Sepsis
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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.
International journal of antimicrobial agents
Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis.
Scientific reports
Sep 7, 2017
Sepsis is a leading cause of death and is the most expensive condition to treat in U.S. hospitals. Despite targeted efforts to automate earlier detection of sepsis, current techniques rely exclusively on using either standard clinical data or novel b...
Learning representations for the early detection of sepsis with deep neural networks.
Computers in biology and medicine
Aug 19, 2017
BACKGROUND: Sepsis is one of the leading causes of death in intensive care unit patients. Early detection of sepsis is vital because mortality increases as the sepsis stage worsens.
Accelerating Chart Review Using Automated Methods on Electronic Health Record Data for Postoperative Complications.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Feb 10, 2017
Manual Chart Review (MCR) is an important but labor-intensive task for clinical research and quality improvement. In this study, aiming to accelerate the process of extracting postoperative outcomes from medical charts, we developed an automated post...
A Model-Based Machine Learning Approach to Probing Autonomic Regulation From Nonstationary Vital-Sign Time Series.
IEEE journal of biomedical and health informatics
Dec 7, 2016
Physiological variables, such as heart rate (HR), blood pressure (BP) and respiration (RESP), are tightly regulated and coupled under healthy conditions, and a break-down in the coupling has been associated with aging and disease. We present an appro...
Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.
The Journal of surgical research
Nov 11, 2016
BACKGROUND: Temporary abdominal closure (TAC) may be performed for cirrhotic patients undergoing emergent laparotomy. The effects of cirrhosis on physiologic parameters, resuscitation requirements, and outcomes following TAC are unknown. We hypothesi...
Negative-Pressure Wound Therapy
Wounds and Injuries
Aged
Treatment Outcome
Aged, 80 and over
Middle Aged
Humans
Follow-Up Studies
Young Adult
Emergencies
Retrospective Studies
Laparotomy
Adult
Sepsis
Female
Abdominal Wound Closure Techniques
Male
Adolescent
Risk Factors
Intra-Abdominal Hypertension
Liver Cirrhosis
Application of Machine Learning Techniques to High-Dimensional Clinical Data to Forecast Postoperative Complications.
PloS one
May 27, 2016
OBJECTIVE: To compare performance of risk prediction models for forecasting postoperative sepsis and acute kidney injury.
Prediction of In-hospital Mortality in Emergency Department Patients With Sepsis: A Local Big Data-Driven, Machine Learning Approach.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Feb 13, 2016
OBJECTIVES: Predictive analytics in emergency care has mostly been limited to the use of clinical decision rules (CDRs) in the form of simple heuristics and scoring systems. In the development of CDRs, limitations in analytic methods and concerns wit...
Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.
The Journal of surgical research
Dec 30, 2015
BACKGROUND: As a common and life-threatening infectious syndrome, sepsis contributes significantly to morbidity and mortality in clinical settings. Vascular endothelial injury and hyperpermeability play an important role in the development of sepsis-...
Serial change of C1 inhibitor in patients with sepsis--a preliminary report.
The American journal of emergency medicine
Dec 19, 2015
OBJECTIVE: C1 inhibitor (C1INH) regulates not only the complement system but also the plasma kallikrein-kinin, fibrinolytic, and coagulation systems. The biologic activities of C1INH can be divided into the regulation of vascular permeability and ant...
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