AIMC Topic: Signal Transduction

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Basic fibroblast growth factor is critical to reprogramming buffalo (Bubalus bubalis) primordial germ cells into embryonic germ stem cell-like cells.

Theriogenology Dec 29, 2016
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major...
Animals Cell Culture Techniques Cell Differentiation Signal Transduction Cell Lineage Fibroblast Growth Factors Embryonic Germ Cells Cellular Reprogramming Buffaloes Pluripotent Stem Cells MAP Kinase Signaling System
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Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues.

Scientific reports Dec 21, 2016
The Dishevelled/EGL-10/Pleckstrin (DEP) domain-containing (DEPDC) proteins have seven members. However, whether this superfamily can be distinguished from other proteins based only on the amino acid sequences, remains unknown. Here, we describe a com...
Protein Domains Amino Acid Motifs GTPase-Activating Proteins Dishevelled Proteins Real-Time Polymerase Chain Reaction Liver Neoplasms Carcinoma, Hepatocellular Machine Learning Computational Biology Algorithms RNA, Messenger Phylogeny Gene Expression Regulation, Neoplastic Humans Gene Expression Profiling Signal Transduction Cluster Analysis
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Spatial dispersal of bacterial colonies induces a dynamical transition from local to global quorum sensing.

Physical review. E Dec 21, 2016
Bacteria communicate using external chemical signals called autoinducers (AI) in a process known as quorum sensing (QS). QS efficiency is reduced by both limitations of AI diffusion and potential interference from neighboring strains. There is thus a...
Signal Transduction Models, Biological Bacterial Physiological Phenomena Quorum Sensing
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Predictive diagnosis of major depression using NMR-based metabolomics and least-squares support vector machine.

Clinica chimica acta; international journal of clinical chemistry Dec 5, 2016
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment an...
Humans Female Adult Male Least-Squares Analysis Lipid Metabolism Glucose Magnetic Resonance Spectroscopy Depressive Disorder, Major Signal Transduction Support Vector Machine Metabolomics
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The method for breast cancer grade prediction and pathway analysis based on improved multiple kernel learning.

Journal of bioinformatics and computational biology Nov 29, 2016
Breast cancer histologic grade represents the morphological assessment of the tumor's malignancy and aggressiveness, which is vital in clinically planning treatment and estimating prognosis for patients. Therefore, the prediction of breast cancer gra...
Humans Machine Learning Genomics Gene Expression Regulation, Neoplastic Signal Transduction Support Vector Machine Algorithms Databases, Factual Female Breast Neoplasms DNA Methylation Neoplasm Grading
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Analysis of Important Gene Ontology Terms and Biological Pathways Related to Pancreatic Cancer.

BioMed research international Nov 9, 2016
Pancreatic cancer is a serious disease that results in more than thirty thousand deaths around the world per year. To design effective treatments, many investigators have devoted themselves to the study of biological processes and mechanisms underlyi...
Humans Signal Transduction Databases, Genetic Pancreatic Neoplasms Gene Ontology
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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
RNA Nucleotidyltransferases Sterol Regulatory Element Binding Protein 1 fas Receptor Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Organic Cation Transport Proteins Stearoyl-CoA Desaturase Signal Transduction Lipogenesis Muscle, Skeletal Adaptation, Physiological Mice, Knockout Glucose Animals PPAR alpha Mice Fatty Acids Insulin Resistance Triglycerides Administration, Oral Microtubule-Associated Proteins Choline Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Gene Expression Regulation
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Modelling with ANIMO: between fuzzy logic and differential equations.

BMC systems biology Jul 27, 2016
BACKGROUND: Computational support is essential in order to reason on the dynamics of biological systems. We have developed the software tool ANIMO (Analysis of Networks with Interactive MOdeling) to provide such computational support and allow insigh...
Fuzzy Logic HT29 Cells Drosophila melanogaster Circadian Clocks Epidermal Growth Factor Tumor Necrosis Factor-alpha Animals Computational Biology Signal Transduction Humans Software
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Confirming an integrated pathology of diabetes and its complications by molecular biomarker-target network analysis.

Molecular medicine reports Jul 7, 2016
Despite ongoing research into diabetes and its complications, the underlying molecular associations remain to be elucidated. The systematic identification of molecular interactions in associated diseases may be approached using a network analysis str...
Models, Biological Diabetes Complications Gene Regulatory Networks Signal Transduction Diabetes Mellitus Metabolic Networks and Pathways Humans Neural Networks, Computer Biomarkers
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Classification of Motor Imagery EEG Signals with Support Vector Machines and Particle Swarm Optimization.

Computational and mathematical methods in medicine May 30, 2016
Support vector machines are powerful tools used to solve the small sample and nonlinear classification problems, but their ultimate classification performance depends heavily upon the selection of appropriate kernel and penalty parameters. In this st...
Imagination Principal Component Analysis Adult Electroencephalography Signal Transduction Signal Processing, Computer-Assisted Humans Support Vector Machine Hand Healthy Volunteers Algorithms Models, Statistical Foot Computer Simulation Motor Skills Reproducibility of Results Movement
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