AIMC Topic: Signal Transduction
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Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals.
Cell
Apr 8, 2025
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challenges to ex...
Root of Prunus persica (taoshugen) ameliorated renal fibrosis by inhibiting TGF-β signaling via upregulating Pmepa1 in mice with unilateral ureter obstruction.
Journal of ethnopharmacology
Apr 3, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
Therapeutic potential of allosteric HECT E3 ligase inhibition.
Cell
Apr 2, 2025
Targeting ubiquitin E3 ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches for identifying inhibitors. In a large, unbiased biochemical screen, we discover inhibitors that bind a crypt...
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.
Cell genomics
Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Phosphoproteins
Trophoblasts
Enhancer Elements, Genetic
Muscle Proteins
Hippo Signaling Pathway
YAP-Signaling Proteins
TEA Domain Transcription Factors
Protein Serine-Threonine Kinases
Adaptor Proteins, Signal Transducing
DNA-Binding Proteins
Mice
Molecular Dynamics Simulation
Signal Transduction
Animals
Transcription Factors
Deep Learning
Protein Binding
Deciphering the dark cancer phosphoproteome using machine-learned co-regulation of phosphosites.
Nature communications
Mar 20, 2025
Mass spectrometry-based phosphoproteomics offers a comprehensive view of protein phosphorylation, yet our limited knowledge about the regulation and function of most phosphosites hampers the extraction of meaningful biological insights. To address th...
Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.
Cellular signalling
Mar 11, 2025
OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute panc...
Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs.
Biochemistry
Mar 8, 2025
G protein-coupled receptors (GPCRs) remain a focal point of research due to their critical roles in cell signaling and their prominence as drug targets. However, directly linking drug efficacy to the receptor-mediated activation of specific intracell...
Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America
Mar 4, 2025
Cardiomyocyte hypertrophy is a key clinical predictor of heart failure. High-throughput and AI-driven screens have the potential to identify drugs and downstream pathways that modulate cardiomyocyte hypertrophy. Here, we developed LogiRx, a logic-bas...
GALR1 and PENK serve as potential biomarkers in invasive non-functional pituitary neuroendocrine tumours.
Gene
Feb 28, 2025
BACKGROUND: Some nonfunctioning pituitary neuroendocrine tumor (NFPitNET) can show invasive growth, which increases the difficulty of surgery and indicates a poor prognosis. However, the molecular mechanism related to invasiveness remains to be furth...
Machine learning-based integration reveals immunological heterogeneity and the clinical potential of T cell receptor (TCR) gene pattern in hepatocellular carcinoma.
Apoptosis : an international journal on programmed cell death
Feb 4, 2025
The T Cell Receptor (TCR) significantly contributes to tumor immunity, whereas the intricate interplay with the Hepatocellular Carcinoma (HCC) microenvironment and clinical significance remains largely unexplored. Here, we aimed to examine the functi...
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