Critical periods (CPs) during the development of neural networks are widely documented. Activity manipulation during open CPs leads to debilitating effects to the mature neural network. Detailed understanding of the contribution of CPs to network dev...
Anhydroicaritin (AHI), a chemically characterized prenylated flavonoid, exhibits strong and selective cytotoxicity against estrogen receptor-positive (ER+) breast cancer cells. In this study, we aimed to elucidate its molecular and cellular toxicolog...
Biochemical and biophysical research communications
Nov 11, 2025
Osteoarthritis (OA) is the most common degenerative joint disease, and the complexity of its molecular mechanisms has hindered the development of effective diagnostic and therapeutic strategies. In this study, we integrated five independent OA RNA-se...
Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammator...
New psychoactive substances (NPS) targeting human cannabinoid receptor 1 pose a significant threat to society as recreational abusive drugs that have pronounced physiological side effects. These greater adverse effects compared to classical cannabino...
Bovine respiratory disease (BRD) is a multifactorial disease of dairy and beef cattle that involves complex interactions with the host immune system. In the current study, a comprehensive meta-analysis was performed using a P-value combination approa...
Cell-to-cell communication through ligand-receptor (LR) interactions can fundamentally shape the tumor microenvironment and immune responses, but the full spectrum of these interactions in anti-PD-1 therapy remains unexplored. We developed a predicti...
Molecular glues are a new class of tiny compounds that can rewire protein-protein interactions, providing a very selective mechanism to modify immunological signalling pathways. These substances allow immune regulators to be selectively degraded or s...
Interactions between cells coordinate various functions across cell-types in health and disease states. Novel single-cell techniques enable deep investigation of cellular crosstalk at single-cell resolution. Cell-cell communication (CCC) is mediated ...
Colon cancer is one of the leading causes of cancer-related mortality, with liver metastasis commonly complicating its progression and significantly worsening patient prognosis. This study aims to explore the relationship between liver metastasis in ...
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