Neurofilament light chain (NfL), a cytoskeletal protein released during neuronal injury, is a promising biomarker, with elevated levels consistently associated with disease severity and progression in multiple neurological conditions, including Alzhe...
Diabetes mellitus (DM), a prevalent metabolic disorder, poses significant diagnostic and therapeutic challenges, especially, in the early stage diagnosis of diabetes related complications. Accurate early stage diagnosis of diabetes and its complicati...
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...
Thiol compounds can serve as markers for the antioxidant and prognostic status of lymphoma, playing a crucial role in early tumor diagnosis. However, their high polarity and lack of chromophores pose challenges for multivariate analysis. This study a...
Given the crucial role of thiols in maintaining normal physiological functions, it is essential to establish a high-throughput and sensitive analytical method to identify and quantify various thiols accurately. Inspired by the iron porphyrin active c...
Realizing the intelligent analysis of the intracellular reactive oxygen species (ROS) is beneficial to quick diagnosis of diseases. Herein, surface-enhanced Raman spectroscopy (SERS) technology was combined with deep learning to establish a smart det...
Investigation of exposure to toxic vanadium (V) in petrochemical workers is very important for human health, and it must be removed and determined in workplace air and human biological samples. In this research, the enriched adsorbent based on the th...
Regression modeling is becoming increasingly prevalent in organic chemistry as a tool for reaction outcome prediction and mechanistic interrogation. Frequently, to acquire the requisite amount of data for such studies, researchers employ combinatoria...
An imbalance of inflammatory/anti-inflammatory and oxidant/antioxidant molecules has been implicated in the demyelination and axonal damage in multiple sclerosis (MS). The current study aimed to evaluate the plasma levels of tumor necrosis factor (TN...
Cytochrome c (Cyt c) release and cellular pH change are two important mediators of apoptosis. Effective methods to regulate or monitor such two events are therefore highly desired for apoptosis research and cancer cell therapy. Herein, we exploited e...
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