AIMC Topic: Synapses
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Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.
Science translational medicine
Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Concept transfer of synaptic diversity from biological to artificial neural networks.
Nature communications
Jun 2, 2025
Recent developments in artificial neural networks have drawn inspiration from biological neural networks, leveraging the concept of the artificial neuron to model the learning abilities of biological nerve cells. However, while neuroscience has provi...
Neuron-astrocyte associative memory.
Proceedings of the National Academy of Sciences of the United States of America
May 23, 2025
Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, there are no current theories that explain how neurons, synapses, and astrocytes might collectivel...
Light-microscopy-based connectomic reconstruction of mammalian brain tissue.
Nature
May 7, 2025
The information-processing capability of the brain's cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can b...
2D Piezo-Ferro-Opto-Electronic Artificial Synapse for Bio-Inspired Multimodal Sensory Integration.
Advanced materials (Deerfield Beach, Fla.)
Apr 7, 2025
Multimodal sensory integration is vital for the evolution of artificial intelligence, yet current approaches often rely on physically connecting distinct sensing units (such as visual and tactile devices) through external circuits, leading to data tr...
A deep learning framework for automated and generalized synaptic event analysis.
eLife
Mar 5, 2025
Quantitative information about synaptic transmission is key to our understanding of neural function. Spontaneously occurring synaptic events carry fundamental information about synaptic function and plasticity. However, their stochastic nature and lo...
Adaptive Synaptic Scaling in Spiking Networks for Continual Learning and Enhanced Robustness.
IEEE transactions on neural networks and learning systems
Feb 28, 2025
Synaptic plasticity plays a critical role in the expression power of brain neural networks. Among diverse plasticity rules, synaptic scaling presents indispensable effects on homeostasis maintenance and synaptic strength regulation. In the current mo...
Organic Synaptic Transistors Based on a Semiconductor Heterojunction for Artificial Visual and Neuromorphic Functions.
Nano letters
Feb 17, 2025
Visual acuity is the ability of the biological retina to distinguish images. High-sensitivity image acquisition improves the quality of visual perception, making images more recognizable for the visual system. Therefore, developing synaptic phototran...
Reconstruction of Adaptive Leaky Integrate-and-Fire Neuron to Enhance the Spiking Neural Networks Performance by Establishing Complex Dynamics.
IEEE transactions on neural networks and learning systems
Feb 6, 2025
Since digital spiking signals can carry rich information and propagate with low computational consumption, spiking neural networks (SNNs) have received great attention from neuroscientists and are regarded as the future development object of neural n...
The calcitron: A simple neuron model that implements many learning rules via the calcium control hypothesis.
PLoS computational biology
Jan 29, 2025
Theoretical neuroscientists and machine learning researchers have proposed a variety of learning rules to enable artificial neural networks to effectively perform both supervised and unsupervised learning tasks. It is not always clear, however, how t...
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