AIMC Topic: Transcriptome
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On the inconsistency of ℓ -penalised sparse precision matrix estimation.
BMC bioinformatics
Dec 13, 2016
BACKGROUND: Various ℓ -penalised estimation methods such as graphical lasso and CLIME are widely used for sparse precision matrix estimation and learning of undirected network structure from data. Many of these methods have been shown to be consisten...
Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants.
Scientific reports
Nov 11, 2016
Respiratory syncytial virus (RSV) causes infections that range from common cold to severe lower respiratory tract infection requiring high-level medical care. Prediction of the course of disease in individual patients remains challenging at the first...
Comprehensive analysis of epigenetically regulated genes in anergic T cells.
Cellular immunology
Nov 2, 2016
T cell anergy is one of the important mechanisms for immune tolerance. The results of many studies investigating the mechanism for T cell anergy induction have revealed that the expression of several genes was up-regulated in anergic T cells. It has ...
Consistent quantitative gene product expression: #3. Invariance with age.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Oct 18, 2016
The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML)....
Consistent quantitative gene product expression: #2. Antigen intensities on bone marrow cells are invariant between individuals.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Oct 18, 2016
Five reference populations in bone marrow specimens were identified by flow cytometry using specific combinations of reagents in order define the variation of gene product expression intensities both within and between individuals. Mature lymphocytes...
Transcriptomic alterations in Sitophilus zeamais in response to allyl isothiocyanate fumigation.
Pesticide biochemistry and physiology
Oct 11, 2016
To study the fumigation mechanisms of Allyl isothiocyanate (AITC) a promising biorational alternative to present fumigants (phosphine and methyl bromide), and provide theoretical basis for its further development in the control of stored grain pests,...
Detecting Essential Proteins Based on Network Topology, Gene Expression Data, and Gene Ontology Information.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2016
The identification of essential proteins in protein-protein interaction (PPI) networks is of great significance for understanding cellular processes. With the increasing availability of large-scale PPI data, numerous centrality measures based on netw...
Inferring Unknown Biological Function by Integration of GO Annotations and Gene Expression Data.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2016
Characterizing genes with semantic information is an important process regarding the description of gene products. In spite that complete genomes of many organisms have been already sequenced, the biological functions of all of their genes are still ...
Symbiont modulates expression of specific gene categories in Angomonas deanei.
Memorias do Instituto Oswaldo Cruz
Oct 3, 2016
Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosyn...
Identification of informative genes and pathways using an improved penalized support vector machine with a weighting scheme.
Computers in biology and medicine
Aug 4, 2016
Incorporation of pathway knowledge into microarray analysis has brought better biological interpretation of the analysis outcome. However, most pathway data are manually curated without specific biological context. Non-informative genes could be incl...
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