AIMC Topic: United Kingdom

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Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation.

Lancet (London, England)
BACKGROUND: Endoscopic surveillance is the clinical standard for Barrett's oesophagus, but its effectiveness is inconsistent. We have developed a test comprising a pan-oesophageal cell collection device coupled with biomarkers to stratify patients in...

A plasma metabolome-derived model predicts severe liver outcomes of nonalcoholic fatty liver disease in the UK Biobank.

Diabetes, obesity & metabolism
AIMS: Severe liver disease (SLD) in nonalcoholic fatty liver disease (NAFLD) is often diagnosed late due to the long asymptomatic period of progressive fibrosis. We aimed to identify metabolomic profiles associated with SLD and develop a predictive m...

Making waves: Is water quality trading a false promise for balancing ecology and economy?

Water research
Agriculture is a major contributor to water pollution through nutrient runoff and excessive water use, exacerbating global water scarcity and ecosystem degradation. Water Quality Trading (WQT) has emerged as a market-based mechanism to address this i...

AI integration and workforce development: Exploring job autonomy and creative self-efficacy in a global context.

PloS one
This paper explores the relationship between Artificial Intelligence (AI) integration in the workplace, cultural orientation, and its impact on job autonomy and creative self-efficacy. Our study employs a mixed-method experimental design across 480 i...

Performance of deep-learning-based approaches to improve polygenic scores.

Nature communications
Polygenic scores, which estimate an individual's genetic propensity for a disease or trait, have the potential to become part of genomic healthcare. Neural-network based deep-learning has emerged as a method of intense interest to model complex, nonl...

The Role of Digital Health Equity Audits in Preventing Harmful Infodemiology.

JMIR infodemiology
BACKGROUND: Health disparities persist and are influenced by digital transformation. Although digital tools offer opportunities, they can also exacerbate existing inequalities, a problem amplified by the COVID-19 pandemic and the related infodemic. H...

Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohort.

eLife
BACKGROUND: Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in females from the UK Biobank.

Are Diffusion Models Effective Good Feature Extractors for MRI Discriminative Tasks?

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
PURPOSE: Diffusion models (DMs) excel in pixel-level and spatial tasks and are proven feature extractors for 2D image discriminative tasks when pretrained. However, their capabilities in 3D MRI discriminative tasks remain largely untapped. This study...

Exploring Therapists' Approaches to Treating Eating Disorders to Inform User-Centric App Design: Web-Based Interview Study.

JMIR formative research
BACKGROUND: The potential for digital interventions in self-management and treatment of mild to moderate eating disorders (EDs) has already been established. However, apps are infrequently recommended by ED therapists to their clients. Those that are...

Associations between the 24-h Activity Daily Cycle and Incident Dementia.

Medicine and science in sports and exercise
BACKGROUND: Physical activity, sedentary behavior (SB), and sleep all impact the risk of incident dementia, however, engagement in these activities is constrained by the 24-h day. Increasing time spent in one activity necessarily reduces time spent i...