AIMC Topic: Administration, Intravenous

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Disposition of ceftizoxime in Staphylococcal mastitis in Indian crossbred cows.

Veterinary journal (London, England : 1997)
Disposition of ceftizoxime was studied in Indian crossbred cows following a single IV dosing in field conditions. Six healthy lactating and six mastitic crossbred cows were assigned to two groups (Group 1 and Group 2). A single IV administration of c...

The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses.

Veterinary anaesthesia and analgesia
OBJECTIVE: Describe the pharmacokinetics and pharmacodynamics of intravenous hydromorphone in healthy horses.

The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care.

Nature medicine
Sepsis is the third leading cause of death worldwide and the main cause of mortality in hospitals, but the best treatment strategy remains uncertain. In particular, evidence suggests that current practices in the administration of intravenous fluids ...

Plasma and cerebrospinal fluid population pharmacokinetic modeling and simulation of meropenem after intravenous and intrathecal administration in postoperative neurosurgical patients.

Diagnostic microbiology and infectious disease
Combined intravenous and local intrathecal administration of meropenem in patients after craniotomy is widely used to treat intracranial infections. However, the optimal dosing regimen of meropenem has not been investigated, posing a risk to treatmen...

Preoperative cesarean delivery intravenous acetaminophen treatment for postoperative pain control: a randomized double-blinded placebo control trial.

American journal of obstetrics and gynecology
BACKGROUND: The United States currently has an opioid use disorder epidemic and research evaluating ways to minimize the use of opioids postsurgery are needed. One of these options is intravenous acetaminophen. If the use of preoperative intravenous ...

Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS.

Journal of pharmaceutical and biomedical analysis
LNA-i-miR-221, a 13-mer oligonucleotide, is a new miR-221 inhibitor that could be used as a novel drug for multiple myeloma. Herein, an ion-pair reversed phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and va...

Robotic i.v. medication compounding: Recommendations from the international community of APOTECAchemo users.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE: The development of recommendations for advancing automated i.v. medication compounding is described.

Prediction of plasma concentration-time profiles in mice using deep neural network integrated with pharmacokinetic models.

International journal of pharmaceutics
Quantitative structure-activity relationship (QSAR) methods have emerged as powerful tools to streamline non-clinical pharmacokinetic (PK) studies, with extensive evidence demonstrating their potential to predict key in vivo PK parameters such as cle...