AIMC Topic: Aged

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Influence of vitamin D and calcium-sensing receptor gene variants on calcium metabolism in end-stage renal disease: insights from machine learning analysis.

European review for medical and pharmacological sciences
OBJECTIVE: End-stage renal disease (ESRD) commonly manifests with disrupted calcium balance, leading to renal osteodystrophy. We posited that variations in the genetic makeup of vitamin D and calcium-sensing receptors, specifically single nucleotide ...

Deep Learning and Single-Cell Sequencing Analyses Unveiling Key Molecular Features in the Progression of Carotid Atherosclerotic Plaque.

Journal of cellular and molecular medicine
Rupture of advanced carotid atherosclerotic plaques increases the risk of ischaemic stroke, which has significant global morbidity and mortality rates. However, the specific characteristics of immune cells with dysregulated function and proven biomar...

Deep Learning Algorithms for Breast Cancer Detection in a UK Screening Cohort: As Stand-alone Readers and Combined with Human Readers.

Radiology
Background Deep learning (DL) algorithms have shown promising results in mammographic screening either compared to a single reader or, when deployed in conjunction with a human reader, compared with double reading. Purpose To externally validate the ...

Development of a Serum Metabolome-Based Test for Early-Stage Detection of Multiple Cancers.

Cancer reports (Hoboken, N.J.)
BACKGROUND: Detection of cancer at the early stage currently offers the only viable strategy for reducing disease-related morbidity and mortality. Various approaches for multi-cancer early detection are being explored, which largely rely on capturing...

Integrating real-world data and machine learning: A framework to assess covariate importance in real-world use of alternative intravenous dosing regimens for atezolizumab.

Clinical and translational science
The increase in the availability of real-world data (RWD), in combination with advances in machine learning (ML) methods, provides a unique opportunity for the integration of the two to explore complex clinical pharmacology questions. Here we present...

Machine Learning Models to Predict Bone Metastasis Risk in Patients With Lung Cancer.

Cancer medicine
INTRODUCTION: The aim of this study was to find the most appropriate variables to input into machine learning algorithms to identify those patients with primary lung malignancy with high risk for metastasis to the bone.

Can machine learning models improve the prediction of surgical site infection in abdominal surgery than traditional statistical models?

The Journal of international medical research
OBJECTIVE: To externally validate by revision and update the study on the efficacy of nosocomial infection control (SENIC) model of surgical site infection (SSI) using logistic regression (LR) and machine learning (ML) approaches.

Accelerating Brain MR Imaging With Multisequence and Convolutional Neural Networks.

Brain and behavior
PURPOSE: Magnetic resonance imaging (MRI) refers to one of the critical image modalities for diagnosis, whereas its long acquisition time limits its application. In this study, the aim was to investigate whether deep learning-based techniques are cap...

Proactive care management of AI-identified at-risk patients decreases preventable admissions.

The American journal of managed care
OBJECTIVES: We assessed whether proactive care management for artificial intelligence (AI)-identified at-risk patients reduced preventable emergency department (ED) visits and hospital admissions (HAs).

Early Detection of Left Ventricular Dysfunction With Machine Learning-Based Strain Imaging in Aortic Stenosis Patients.

Echocardiography (Mount Kisco, N.Y.)
PURPOSE: Aortic stenosis (AS) is a common cardiovascular condition where early detection of left ventricular (LV) dysfunction is essential for timely intervention and optimal management. Current echocardiographic measurements, such as ejection fracti...