AIMC Topic: Aged

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Cognitive driven gait freezing phase detection and classification for neuro-rehabilitated patients using machine learning algorithms.

Journal of neuroscience methods
BACKGROUND: The significance of diagnosing illnesses associated with brain cognitive and gait freezing phase patterns has led to a recent surge in interest in the study of gait for mental disorders. A more precise and effective way to characterize an...

Integrated biomarker profiling for predicting the response of type 2 diabetes to metformin.

Diabetes, obesity & metabolism
AIM: To explore biomarkers that can predict the response of type 2 diabetes (T2D) patients to metformin at an early stage to provide better treatment for T2D.

Identifying patients with undiagnosed small intestinal neuroendocrine tumours in primary care using statistical and machine learning: model development and validation study.

British journal of cancer
BACKGROUND: Neuroendocrine tumours (NETs) are increasing in incidence, often diagnosed at advanced stages, and individuals may experience years of diagnostic delay, particularly when arising from the small intestine (SI). Clinical prediction models c...

Optimizing Rare Disease Gait Classification through Data Balancing and Generative AI: Insights from Hereditary Cerebellar Ataxia.

Sensors (Basel, Switzerland)
The interpretability of gait analysis studies in people with rare diseases, such as those with primary hereditary cerebellar ataxia (pwCA), is frequently limited by the small sample sizes and unbalanced datasets. The purpose of this study was to asse...

Identification of shared gene signatures and pathways for diagnosing osteoporosis with sarcopenia through integrated bioinformatics analysis and machine learning.

BMC musculoskeletal disorders
BACKGROUND: Prior studies have suggested a potential relationship between osteoporosis and sarcopenia, both of which can present symptoms of compromised mobility. Additionally, fractures among the elderly are often considered a common outcome of both...

Deep learning-based risk stratification of preoperative breast biopsies using digital whole slide images.

Breast cancer research : BCR
BACKGROUND: Nottingham histological grade (NHG) is a well established prognostic factor in breast cancer histopathology but has a high inter-assessor variability with many tumours being classified as intermediate grade, NHG2. Here, we evaluate if Dee...

Prognostic biomarkers of intracerebral hemorrhage identified using targeted proteomics and machine learning algorithms.

PloS one
Early prognostication of patient outcomes in intracerebral hemorrhage (ICH) is critical for patient care. We aim to investigate protein biomarkers' role in prognosticating outcomes in ICH patients. We assessed 22 protein biomarkers using targeted pro...

Automatic Recognition of Auditory Brainstem Response Waveforms Using a Deep Learning-Based Framework.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
OBJECTIVE: Recognition of auditory brainstem response (ABR) waveforms may be challenging, particularly for older individuals or those with hearing loss. This study aimed to investigate deep learning frameworks to improve the automatic recognition of ...

Machine learning-based model for predicting outcomes in cerebral hemorrhage patients with leukemia.

European journal of radiology
BACKGROUND AND PURPOSE: Intracranial hemorrhage (ICH) in leukemia patients progresses rapidly with high mortality. Limited data are available on imaging studies in this population. The study aims to develop prediction models for 7-day and short-term ...