AIMC Topic: Amyloid beta-Peptides
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Application of artificial neural network model in diagnosis of Alzheimer's disease.
BMC neurology
Jul 8, 2019
BACKGROUND: Alzheimer's disease has become a public health crisis globally due to its increasing incidence. The purpose of this study was to establish an early warning model using artificial neural network (ANN) for early diagnosis of AD and to explo...
Antemortem CSF A42/A40 ratio predicts Alzheimer's disease pathology better than A42 in rapidly progressive dementias.
Annals of clinical and translational neurology
Dec 14, 2018
OBJECTIVE: Despite the critical importance of pathologically confirmed samples for biomarker validation, only a few studies have correlated CSF A42 values in vivo with postmortem Alzheimer's disease (AD) pathology, while none evaluated the CSF A42/A4...
AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure.
NeuroImage
Jul 26, 2017
Utilizing [18F]-AV-1451 tau positron emission tomography (PET) as an Alzheimer disease (AD) biomarker will require identification of brain regions that are most important in detecting elevated tau pathology in preclinical AD. Here, we utilized an uns...
Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease.
Journal of food and drug analysis
Mar 17, 2017
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. β-Amyloid (Aβ) has been proposed to play a role in the pathogenesis of AD. Deposits of insoluble Aβ are found in the brains of patients with AD and are one of the pathologi...
CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD.
Neurobiology of aging
Nov 2, 2015
Cerebrospinal fluid (CSF) concentrations of YKL-40 that serve as biomarker of neuroinflammation are known to be altered along the clinico-biological continuum of Alzheimer's disease (AD). The specific structural cerebral correlates of CSF YKL-40 were...
Prediction Model and Nomogram for Amyloid Positivity Using Clinical and MRI Features in Individuals With Subjective Cognitive Decline.
Human brain mapping
Jun 1, 2025
There is an urgent need for the precise prediction of cerebral amyloidosis using noninvasive and accessible indicators to facilitate the early diagnosis of individuals with the preclinical stage of Alzheimer's disease (AD). Two hundred and four indiv...
Predicting and preventing Alzheimer's disease.
Science (New York, N.Y.)
May 29, 2025
With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer's disease years before signs of even mild cognitive...
Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Mar 1, 2025
BACKGROUND: Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estim...
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome.
Journal of neuropathology and experimental neurology
Nov 1, 2024
Neuropathologic changes of Alzheimer disease (AD) including Aβ accumulation and neuroinflammation are frequently observed in the cerebral cortex of patients with idiopathic normal pressure hydrocephalus (iNPH). We created an automated analysis platfo...
A Study on Machine Learning Models in Detecting Cognitive Impairments in Alzheimer's Patients Using Cerebrospinal Fluid Biomarkers.
American journal of Alzheimer's disease and other dementias
Jan 1, 2024
Several research studies have demonstrated the potential use of cerebrospinal fluid biomarkers such as amyloid beta 1-42, T-tau, and P-tau, in early diagnosis of Alzheimer's disease stages. The levels of these biomarkers in conjunction with the demen...
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