AIMC Topic: Animals

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Neural encoding of temporal and spatial plausibility in naturalistic motion: an awake monkey fMRI study.

Neuropsychologia
Time flows in one direction, a physical constraint humans recognize, as reflected in proverbs such as "there is no crying over spilt milk." Recent work from our laboratory has demonstrated that human participants rely on specific cues to discriminate...

Telomere-targeted medicine: Bridging molecular mechanisms and clinical applications in age-related diseases.

Life sciences
Telomeres, the nucleoprotein structures at the ends of chromosomes, have emerged as critical regulators of cellular aging and key contributors to the pathogenesis of age-related diseases. This comprehensive review examines the evolution of telomere b...

"The emerging pandemic threat of H5N1: Evolutionary adaptations for human transmission, zoonotic spillovers and surveillance gaps".

Gene
The increasing zoonotic potential of highly pathogenic avian influenza (HPAI) H5N1 poses a growing threat to global public health. This review examines the molecular and evolutionary mechanisms facilitating H5N1 adaptation in mammalian hosts, focusin...

Design and realization of a low-drive bionic frog robot.

Bioinspiration & biomimetics
This paper presents the design and fabrication of a compact underdriven bionic frog robot, which is inspired by the locomotion stance of a frog. The robot's hind legs were ingeniously built using an underdriven associative 8-bar linkage mechanism wit...

Computationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics.

Nature communications
Identifying carbon-carbon double bond (C=C) positions in complex lipids is essential for elucidating physiological and pathological processes. Currently, this is impossible in high-throughput analyses of native lipids without specialized instrumentat...

Recent developments in omics studies and artificial intelligence in depression and suicide.

Translational psychiatry
Major depressive disorder (MDD) is the most prevalent and severe form of mental illness and is significantly linked to suicide. At present, addressing the treatment and prevention of depression and suicide poses significant challenges, largely due to...

Impact of deep learning and post-processing algorithms performances on biodiversity metrics assessed on videos.

PloS one
Assessing the escalating biodiversity crisis, driven by climate change, habitat destruction, and exploitation, necessitates efficient monitoring strategies to assess species presence and abundance across diverse habitats. Video-based surveys using re...

Advancements in the investigation of the mechanisms underlying cognitive aging.

Biogerontology
Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to...

Emerging trends in NanoTheranostics: Integrating imaging and therapy for precision health care.

International journal of pharmaceutics
Nanotheranostics has garnered significant interest for its capacity to improve customized healthcare via targeted and efficient treatment alternatives. Nanotheranostics promises an innovative approach to precision medicine by integrating therapeutic ...

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.

Nature communications
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...