AI Medical Compendium Topic:
Area Under Curve

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Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL.

Clinical pharmacology in drug development Oct 5, 2015
Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin doses. This phase 1, open-label, 2-sequence, 4-period crossover, randomiz...
Cross-Over Studies Humans Therapeutic Equivalency Female Middle Aged Glucose Clamp Technique Young Adult Hypoglycemic Agents Insulin Lispro Adult Dose-Response Relationship, Drug Male Area Under Curve
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Genome-wide prediction of prokaryotic two-component system networks using a sequence-based meta-predictor.

BMC bioinformatics Sep 18, 2015
BACKGROUND: Two component systems (TCS) are signalling complexes manifested by a histidine kinase (receptor) and a response regulator (effector). They are the most abundant signalling pathways in prokaryotes and control a wide range of biological pro...
Protein Kinases Genome, Bacterial Histidine Kinase Bacteria Support Vector Machine Area Under Curve Bacterial Proteins ROC Curve Protein Interaction Maps
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Going beyond a First Reader: A Machine Learning Methodology for Optimizing Cost and Performance in Breast Ultrasound Diagnosis.

Ultrasound in medicine & biology Sep 6, 2015
The goal of this study was to devise a machine learning methodology as a viable low-cost alternative to a second reader to help augment physicians' interpretations of breast ultrasound images in differentiating benign and malignant masses. Two indepe...
Humans Middle Aged Image Processing, Computer-Assisted Area Under Curve Ultrasonography, Mammary Observer Variation Machine Learning Female Sensitivity and Specificity Breast Neoplasms
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Pharmacokinetics of aclidinium bromide/formoterol fumarate fixed-dose combination compared with individual components: A phase 1, open-label, single-dose study.

Clinical pharmacology in drug development Aug 24, 2015
Inhaled, long-acting bronchodilators represent a cornerstone of maintenance treatment for chronic obstructive pulmonary disease (COPD). Aclidinium bromide/formoterol fumarate 400/12 μg fixed-dose combination (FDC) has recently been licensed for use i...
Tropanes Bronchodilator Agents Formoterol Fumarate Male Humans Drug Combinations Area Under Curve Female Biological Availability Young Adult Adult
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Machine Learning methods for Quantitative Radiomic Biomarkers.

Scientific reports Aug 17, 2015
Radiomics extracts and mines large number of medical imaging features quantifying tumor phenotypic characteristics. Highly accurate and reliable machine-learning approaches can drive the success of radiomic applications in clinical care. In this radi...
Area Under Curve Survival Analysis Humans Machine Learning Tomography, X-Ray Computed Biomarkers, Tumor ROC Curve Lung Neoplasms Carcinoma, Non-Small-Cell Lung
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Pharmacokinetic profiles of meloxicam in turtles (Trachemys scripta scripta) after single oral, intracoelomic and intramuscular administrations.

Journal of veterinary pharmacology and therapeutics Aug 12, 2015
Meloxicam is an anti-inflammatory and analgesic drug used to treat many pathological conditions in turtles. With the aim to fill the lack of data about its pharmacokinetic in this species, eighteen turtles (Trachemys scripta scripta) were divided in ...
Half-Life Female Animals Thiazoles Anti-Inflammatory Agents, Non-Steroidal Turtles Area Under Curve Thiazines Drug Administration Routes Meloxicam
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Prediction of Allogeneic Hematopoietic Stem-Cell Transplantation Mortality 100 Days After Transplantation Using a Machine Learning Algorithm: A European Group for Blood and Marrow Transplantation Acute Leukemia Working Party Retrospective Data Mining Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Aug 3, 2015
PURPOSE: Allogeneic hematopoietic stem-cell transplantation (HSCT) is potentially curative for acute leukemia (AL), but carries considerable risk. Machine learning algorithms, which are part of the data mining (DM) approach, may serve for transplanta...
Algorithms Decision Support Techniques Retrospective Studies Female Humans Machine Learning Male Middle Aged Risk Assessment Postoperative Complications Disease Progression Reproducibility of Results Risk Factors Adult Leukemia, Myeloid, Acute Registries Disease-Free Survival Data Mining Hematopoietic Stem Cell Transplantation Europe Kaplan-Meier Estimate Time Factors Transplantation, Homologous Decision Trees Precursor Cell Lymphoblastic Leukemia-Lymphoma ROC Curve Predictive Value of Tests Logistic Models Area Under Curve Treatment Outcome
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High-order neural networks and kernel methods for peptide-MHC binding prediction.

Bioinformatics (Oxford, England) Jul 23, 2015
MOTIVATION: Effective computational methods for peptide-protein binding prediction can greatly help clinical peptide vaccine search and design. However, previous computational methods fail to capture key nonlinear high-order dependencies between diff...
Humans Epitopes Amino Acid Sequence Molecular Sequence Data Major Histocompatibility Complex Protein Binding Support Vector Machine Databases, Protein Area Under Curve Neural Networks, Computer Algorithms Peptides ROC Curve
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Sample Selection for Training Cascade Detectors.

PloS one Jul 21, 2015
Automatic detection systems usually require large and representative training datasets in order to obtain good detection and false positive rates. Training datasets are such that the positive set has few samples and/or the negative set should represe...
Computational Biology Mammography Area Under Curve Radiographic Image Interpretation, Computer-Assisted False Positive Reactions Facial Recognition Pedestrians Pattern Recognition, Automated Databases, Factual Female Breast Neoplasms ROC Curve Humans Artificial Intelligence Algorithms
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Automated generation of directed graphs from vascular segmentations.

Journal of biomedical informatics Jul 9, 2015
Automated feature extraction from medical images is an important task in imaging informatics. We describe a graph-based technique for automatically identifying vascular substructures within a vascular tree segmentation. We illustrate our technique us...
Pulmonary Artery Least-Squares Analysis Automation Angiography Aorta ROC Curve Imaging, Three-Dimensional Image Processing, Computer-Assisted Area Under Curve Software Algorithms Tomography, X-Ray Computed Humans Machine Learning
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