AIMC Topic: Biomarkers

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Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands.

The Journal of clinical endocrinology and metabolism
CONTEXT: Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response to first-generation somatostatin receptor ligands (fg-SRLs) in the treatment of acromegaly.

Discovery of molecular features underlying the morphological landscape by integrating spatial transcriptomic data with deep features of tissue images.

Nucleic acids research
Profiling molecular features associated with the morphological landscape of tissue is crucial for investigating the structural and spatial patterns that underlie the biological function of tissues. In this study, we present a new method, spatial gene...

Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.

Brain imaging and behavior
High dimensional neuroimaging datasets and machine learning have been used to estimate and predict domain-specific cognition, but comparisons with simpler models composed of easy-to-measure variables are limited. Regularization methods in particular ...

Integrative biomarker detection on high-dimensional gene expression data sets: a survey on prior knowledge approaches.

Briefings in bioinformatics
Gene expression data provide the expression levels of tens of thousands of genes from several hundred samples. These data are analyzed to detect biomarkers that can be of prognostic or diagnostic use. Traditionally, biomarker detection for gene expre...

Imaging Biomarkers of 1-Year Activity in Type 1 Macular Neovascularization.

Translational vision science & technology
PURPOSE: The purpose of this study was to evaluate the predictive value of optical coherence tomography (OCT) and OCT angiography (OCTA) parameters at baseline on lesion's activity at the 1-year follow-up in type 1 macular neovascularizations (MNVs) ...

Four Biomarkers-Based Artificial Neural Network Model for Accurate Early Prediction of Bacteremia with Low-level Procalcitonin.

Annals of clinical and laboratory science
OBJECTIVE: Procalcitonin levels above 2.0 ng/mL are associated with a higher risk of severe sepsis. Bacteremia with procalcitonin levels lower than 2.0 ng/mL has not received much attention, and relevant prediction models are lacking. Herein, a panel...

Artificial intelligence for automating the measurement of histologic image biomarkers.

The Journal of clinical investigation
Artificial intelligence has been applied to histopathology for decades, but the recent increase in interest is attributable to well-publicized successes in the application of deep-learning techniques, such as convolutional neural networks, for image ...

Machine Learning-Driven Metabolomic Evaluation of Cerebrospinal Fluid: Insights Into Poor Outcomes After Aneurysmal Subarachnoid Hemorrhage.

Neurosurgery
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with a high mortality and poor neurologic outcomes. The biologic underpinnings of the morbidity and mortality associated with aSAH remain poorly understood.

Deep learning in systems medicine.

Briefings in bioinformatics
Systems medicine (SM) has emerged as a powerful tool for studying the human body at the systems level with the aim of improving our understanding, prevention and treatment of complex diseases. Being able to automatically extract relevant features nee...