AIMC Topic: Biomarkers
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Non-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 31, 2024
Moyamoya disease (MMD) is a progressive cerebrovascular disorder that increases the risk of intracranial ischemia and hemorrhage. Timely diagnosis and intervention can significantly reduce the risk of new-onset stroke in patients with MMD. However, t...
Identification of sepsis-associated encephalopathy biomarkers through machine learning and bioinformatics approaches.
Scientific reports
Dec 30, 2024
Sepsis-associated encephalopathy (SAE) is common in septic patients, characterized by acute and long-term cognitive impairment, and is associated with higher mortality. This study aimed to identify SAE-related biomarkers and evaluate their diagnostic...
Novel anoikis-related diagnostic biomarkers for aortic dissection based on machine learning.
Scientific reports
Dec 28, 2024
Aortic dissection (AD) is one of the most dangerous diseases of the cardiovascular system, which is characterized by acute onset and poor prognosis, while the pathogenesis of AD is still unclear and may affect or even delay the diagnosis of AD. Ancho...
Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells.
Scientific reports
Dec 28, 2024
Double negative T (DNT) cells are a unique subset of CD3 + TCRαβ + T lymphocytes that lack CD4, CD8, or NK1.1 expression and constitute 3-5% of the total T cell population in C57BL/6 mice. They have increasingly gained recognition for their novel rol...
Interpretable machine learning-driven biomarker identification and validation for Alzheimer's disease.
Scientific reports
Dec 28, 2024
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by limited effective treatments, underscoring the critical need for early detection and diagnosis to improve intervention outcomes. This study integrates various bioinformatics me...
Association between serum endocan levels and organ failure in hospitalized patients with cirrhosis.
PloS one
Dec 26, 2024
BACKGROUND & AIMS: Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endoth...
The predictive value of heparin-binding protein for bacterial infections in patients with severe polytrauma.
PloS one
Dec 26, 2024
INTRODUCTION: Heparin-binding protein is an inflammatory factor with predictive value for sepsis and participates in the inflammatory response through antibacterial effects, chemotaxis, and increased vascular permeability. The role of heparin-binding...
Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype.
Aging cell
Dec 25, 2024
Proteome changes associated with APOE4 variant carriage that are independent of Alzheimer's disease (AD) pathology and diagnosis are unknown. This study investigated APOE4 proteome changes in people with AD, mild cognitive impairment, and no impairme...
A comprehensive and bias-free machine learning approach for risk prediction of preeclampsia with severe features in a nulliparous study cohort.
BMC pregnancy and childbirth
Dec 24, 2024
Preeclampsia is one of the leading causes of maternal morbidity, with consequences during and after pregnancy. Because of its diverse clinical presentation, preeclampsia is an adverse pregnancy outcome that is uniquely challenging to predict and mana...
Nonlinear relationship between serum Klotho and chronic kidney disease in US adults with metabolic syndrome.
Frontiers in endocrinology
Dec 24, 2024
BACKGROUND: Current evidence regarding the effects of serum Klotho among patients with metabolic syndrome (MetS) is scarce. This study explored the relationship between serum Klotho levels and the odds of chronic kidney disease (CKD) in middle-aged a...
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