AIMC Topic: Biomarkers

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Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach.

Frontiers of medicine
Ankylosing spondylitis (AS) is linked to an increased prevalence of myocardial infarction (MI). However, research dedicated to elucidating the pathogenesis of AS-MI is lacking. In this study, we explored the biomarkers for enhancing the diagnostic an...

Recent advances in omics and the integration of multi-omics in osteoarthritis research.

Arthritis research & therapy
Osteoarthritis (OA) is a complex disorder driven by the combination of environmental and genetic factors. Given its high global prevalence and heterogeneity, developing effective and personalized treatment methods is crucial. This requires identifyin...

Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning.

Molecular immunology
Sepsis is a non-discriminatory inflammatory reaction that can result in a diverse array of organ dysfunctions, which can be fatal. Pyroptosis is a programmed mechanism of cell death that is distinguishable from apoptosis and other forms of cellular d...

Role and Potential of Artificial Intelligence in Biomarker Discovery and Development of Treatment Strategies for Amyotrophic Lateral Sclerosis.

International journal of molecular sciences
Neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), present significant challenges owing to their complex pathologies and a lack of curative treatments. Early detection and reliable biomarkers are critical but remain elusive. A...

Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis.

International journal of molecular sciences
Peri-implantitis (PI) is a chronic inflammatory disease that ultimately leads to the dysfunction and loss of implants with established osseointegration. Ferroptosis has been implicated in the progression of PI, but its precise mechanisms remain uncle...

Predicting preeclampsia in early pregnancy using clinical and laboratory data via machine learning model.

BMC medical informatics and decision making
BACKGROUND: This study was performed to characterize the relationship of various laboratory test indicators with clinical information and Preeclampsia (PE) development. Then, prediction models for early-onset preeclampsia (EOPE), late-onset preeclamp...

Advancement in early diagnosis of polycystic ovary syndrome: biomarker-driven innovative diagnostic sensor.

Mikrochimica acta
Polycystic ovary syndrome (PCOS) is a heterogeneous multifactorial endocrine disorder that affects one in five women around the globe. The pathology suggests a strong polygenic and epigenetic correlation, along with hormonal and metabolic dysfunction...

Automated extraction of functional biomarkers of verbal and ambulatory ability from multi-institutional clinical notes using large language models.

Journal of neurodevelopmental disorders
BACKGROUND: Functional biomarkers in neurodevelopmental disorders, such as verbal and ambulatory abilities, are essential for clinical care and research activities. Treatment planning, intervention monitoring, and identifying comorbid conditions in i...

Using Machine Learning to Predict Cognitive Decline in Older Adults From the Chinese Longitudinal Healthy Longevity Survey: Model Development and Validation Study.

JMIR aging
BACKGROUND: Cognitive impairment, indicative of Alzheimer disease and other forms of dementia, significantly deteriorates the quality of life of older adult populations and imposes considerable burdens on families and health care systems worldwide. T...