Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Despite advancements in treatment, prognosis for patients with advanced stages remains poor. Metabolic reprogramming in the tumor microenvironment, particularly...
Medical decision making : an international journal of the Society for Medical Decision Making
Jul 4, 2025
BackgroundMachine learning (ML) algorithms may improve the prognosis for serious illnesses such as cancer, identifying patients who may benefit from earlier palliative care (PC) or advance care planning (ACP). We evaluated the impact of various prese...
Beam orientation optimization (BOO) in intensity-modulated radiation therapy (IMRT) is a complex, non-convex problem traditionally addressed with heuristic methods.This work demonstrates the potential improvement of the proposed BOO, providing a math...
Exosomes are crucial in the development of non-small cell lung cancer (NSCLC), yet exosome-associated genes in NSCLC remain insufficiently explored. The present study identified 59 exosome-associated differentially expressed genes (EA-DEGs) from the ...
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Jul 1, 2025
PURPOSE: Radiation Pneumonitis (RP) and Radiation Esophagitis (RE) are two prominent dose limiting toxicities from NSCLC radiotherapy. This study aimed to develop a multi-objective Bayesian network (BN) model to predict multiple NSCLC outcomes simult...
Signal transduction and targeted therapy
Jun 15, 2025
Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitable reality....
BACKGROUND: Next-generation sequencing (NGS) has become a cornerstone of treatment for lung cancer and is recommended in current treatment guidelines for patients with advanced or metastatic disease.
Early detection of non-small cell lung cancer (NSCLC) can improve survival rates, and plasma proteomics may provide effective tools for risk prediction. The population for this study included 52,913 participants and 2911 plasma proteomics from UK Bio...
Lung cancer is the leading cause of cancer mortality among people with HIV (PWH), with increased incidence and poor outcomes. This study explored whether the tumor microenvironment (TME) of HIV-associated non-small cell lung cancer (NSCLC) limits tum...
European journal of nuclear medicine and molecular imaging
Jun 2, 2025
PURPOSE: To develop and validate a novel nomogram combining multi-organ PET metabolic metrics for major pathological response (MPR) prediction in resectable non-small cell lung cancer (rNSCLC) patients receiving neoadjuvant immunochemotherapy.
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.