AIMC Topic: Cell Line, Tumor

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Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.

International immunopharmacology May 31, 2025
Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advanced stages remain uncertain. Cell-cell communication plays a crucial role in the tumor microenvironmen...
Transcriptome Cell Line, Tumor Mice Multiomics Female Tumor Microenvironment Animals Gene Expression Profiling Humans Mice, Nude Prognosis Ligands Endometrial Neoplasms Oncostatin M Oncostatin M Receptor beta Subunit Gene Expression Regulation, Neoplastic Cell Proliferation Signal Transduction Adenocarcinoma
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Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia.

Scientific reports May 30, 2025
BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leukemia (CML) over the past decades. In this study, we reported an unexpected role of neddylation inhibitors in desensitizing the therapeutic efficacy of...
Protein Processing, Post-Translational Drug Resistance, Neoplasm Protein Kinase Inhibitors Fusion Proteins, bcr-abl Leukemia, Myelogenous, Chronic, BCR-ABL Positive Humans Animals Cell Line, Tumor Mice Tyrosine Kinase Inhibitors NEDD8 Protein
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A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy.

Nature communications May 30, 2025
Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and d...
Workflow Cisplatin Mitochondria Aneuploidy Isotope Labeling Drug Resistance, Neoplasm Proteolysis Cell Line, Tumor Proteomics Proteome Mass Spectrometry Humans Machine Learning
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Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration.

Annals of medicine May 29, 2025
OBJECTIVE: Diagnosis of hepatocellular carcinoma (HCC) remains challenging for clinicians. Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.
Mice Gene Expression Regulation, Neoplastic Extracellular Matrix Proteins Thrombospondins Gene Expression Profiling Cell Line, Tumor Liver Neoplasms Carcinoma, Hepatocellular Humans Biomarkers, Tumor Animals Male
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Disulfide bond-related gene signature development for bladder cancer prognosis prediction and immune microenvironment characterization.

Scientific reports May 29, 2025
Bladder cancer is the fourth most common malignant tumor in men, with limited therapeutic biomarkers and heterogeneous responses to immunotherapy. Disulfide bond-driven cell death has emerged as a critical regulator of tumor progression and immune mi...
Immunotherapy Gene Expression Regulation, Neoplastic Urinary Bladder Neoplasms Disulfides Gene Expression Profiling Female Transcriptome Tumor Microenvironment Cell Line, Tumor Humans Biomarkers, Tumor Single-Cell Analysis Male Prognosis
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Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

Nature communications May 23, 2025
Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based mult...
Mice Membrane Proteins Animals Mice, Inbred C57BL Humans Administration, Oral Neoplasms Nucleotides, Cyclic Artificial Intelligence Phosphoric Diester Hydrolases Drug Design Female Cell Line, Tumor Pyrophosphatases
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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.

Frontiers in immunology May 22, 2025
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...
Cell Line, Tumor Tumor Microenvironment CD8-Positive T-Lymphocytes Single-Cell Analysis Amino Acids Male Gene Expression Regulation, Neoplastic Programmed Cell Death 1 Receptor Gene Expression Profiling Lymphocytes, Tumor-Infiltrating Tumor Escape Transcriptome Humans Prognosis Female Colorectal Neoplasms
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Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy.

Science advances May 21, 2025
Neoantigens have emerged as ideal targets for personalized cancer immunotherapy. We depict the pan-cancer peptide atlas by comprehensively collecting immunopeptidomics from 531 samples across 14 cancer and 29 normal tissues, and identify 389,165 cano...
Humans Machine Learning Precision Medicine T-Lymphocytes Cell Line, Tumor Immunotherapy Antigens, Neoplasm Neoplasms Peptides Proteomics
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Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.

Journal of translational medicine May 21, 2025
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
Animals Leukemia, Myeloid, Acute Male Middle Aged Humans Prognosis Female Tumor Microenvironment Cell Death Xenograft Model Antitumor Assays Endoplasmic Reticulum Stress Cell Line, Tumor Mice Apoptosis Models, Biological
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Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements.

Nature communications May 21, 2025
The RAS/ERK pathway plays a central role in diagnosis and therapy for many cancers. ERK activity is highly dynamic within individual cells and drives cell proliferation, metabolism, and other processes through effector proteins including c-Myc, c-Fos...
Humans Machine Learning Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-myc Extracellular Signal-Regulated MAP Kinases Early Growth Response Protein 1 Cell Line, Tumor Biosensing Techniques MAP Kinase Signaling System Fluorescent Antibody Technique
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