Journal of chemical information and modeling
Oct 10, 2025
Effective anticancer drug combinations are crucial for advancing cancer treatment, yet predicting drug synergy remains challenging due to the complexity of biological interactions. Existing methods struggle to integrate multimodal features and to mod...
Emerging evidence suggests that post-translational modifications (PTMs) contribute to osteosarcoma pathogenesis, yet their exact molecular roles require further elucidation. Using the AddModuleScore method, we classified tumor cells on the basis of P...
BACKGROUND: Cutaneous melanoma is a highly invasive tumor. It enhances metastasis and resistance to immunotherapy immunosuppressive mechanisms. Understanding RNA-binding proteins (RBPs) in melanoma's immune alterations is limited. This study explore...
Self-organised three-dimensional (3D) cell cultures, collectively called 3D-oids, include spheroids, organoids and other co-culture models. Systematic evaluation of these models forms a critical new generation of high-content screening (HCS) systems ...
BACKGROUNDS: Consensus molecular subtype 4 (CMS4) of colorectal cancer (CRC) is characterized by TGF-β activation, and generally accompanied with metastasis and recurrence. Nevertheless, molecular biomarkers and regulatory mechanisms underlying CMS4 ...
Fatty acid metabolism is critically involved in glioblastoma (GBM) pathogenesis; however, its regulatory mechanisms remain incompletely understood. In this study, we identified biliverdin reductase A (BLVRA) as a novel metabolic driver and prognostic...
Aurora B, a subtype of Aurora kinases that functions as a serine/threonine kinase, playing a vital role in the process of mitosis, is often overexpressed in certain tumor cells leading to tumorigenesis and progression. Therefore, the development of s...
BACKGROUND: Ovarian cancer (OC) poses a significant public health challenge due to its dismal prognosis and low survival rates. However, the mechanism of OC development remains unclear.
Tumor heterogeneity poses a major challenge to the precision treatment of medulloblastoma (MB). Rapid and accurate subtyping tools are urgently needed for informed clinical decision-making. Herein, we demonstrate the utility of Raman spectroscopy (RS...
Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic ...
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