AIMC Topic: Cell Line
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Feature-Based Representation Improves Color Decomposition and Nuclear Detection Using a Convolutional Neural Network.
IEEE transactions on bio-medical engineering
Mar 1, 2018
Detection of nuclei is an important step in phenotypic profiling of 1) histology sections imaged in bright field; and 2) colony formation of the 3-D cell culture models that are imaged using confocal microscopy. It is shown that feature-based represe...
Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.
Nucleic acids research
Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
[Y-27632 protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy pathway].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Nov 1, 2017
Objective To investigate the protective effect of preconditioning with Rho-kinase inhibitor Y-27632 on H9c2 cardiomyocytes against hypoxia/reoxygenation (H/R) injury, and explore its underlying mechanism. Methods H9c2 cardiomyocytes were divided into...
Denoising genome-wide histone ChIP-seq with convolutional neural networks.
Bioinformatics (Oxford, England)
Jul 15, 2017
MOTIVATION: Chromatin immune-precipitation sequencing (ChIP-seq) experiments are commonly used to obtain genome-wide profiles of histone modifications associated with different types of functional genomic elements. However, the quality of histone ChI...
Chromatin accessibility prediction via convolutional long short-term memory networks with k-mer embedding.
Bioinformatics (Oxford, England)
Jul 15, 2017
MOTIVATION: Experimental techniques for measuring chromatin accessibility are expensive and time consuming, appealing for the development of computational approaches to predict open chromatin regions from DNA sequences. Along this direction, existing...
CONDITIONS OF PROOXIDANT ACTIVITY OF CISTUS AND POMEGRANATE POLYPHENOLS IN V79 CELL CULTURES.
Acta poloniae pharmaceutica
Mar 1, 2017
Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peels (Punica granatunm L.) added at high concentrations (25-100 pg/mL) to V79 (Chinese hamster lung fibroblast) cell cultures, markedly increased intracellular le...
[MiR-142-3p inhibits lipopolysaccharide-induced inflammatory response in human periodontal ligament cells through targeting IRAK1].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2016
PURPOSE: To investigate the effects of miR-142-3p overexpression on secretion of inflammatory factors in human periodontal ligament cells (hPDLCs) induced by lipopolysaccharide (LPS) and its underlying mechanism.
The Effect of Artemisia fragrans Willd: Essential Oil on Inducible Nitric Oxide Synthase Gene Expression and Nitric Oxide Production in Lipopolysaccharide-stimulated Murine Macrophage Cell Line.
Iranian journal of allergy, asthma, and immunology
Dec 1, 2016
The genus Artemisia is estimated to comprise over 800 species with anti-cancer, anti-fungal, anti-oxidant and anti-inflammatory properties. Artemisia fragrans (A. fragrans), a species that belongs to genus Artemisia, is rich in monoterpenes and sesqu...
Rapid acquisition of mean Raman spectra of eukaryotic cells for a robust single cell classification.
The Analyst
Nov 14, 2016
Raman spectroscopy has previously been used to identify eukaryotic and prokaryotic cells. While prokaryotic cells are small in size and can be assessed by a single Raman spectrum, the larger size of eukaryotic cells and their complex organization req...
[The Protective Effect of Tanshinone IIA on Oxygen-glucose Deprivation and Reperfusion Injury of MicrogliaThrough the NLRP3 Inflammatory Signaling Pathway].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Sep 1, 2016
OBJECTIVES: To investigate the protective effect of Tanshinone IIA (TSA) on oxygen-glucose deprivation and reperfusion (OGD/R) injury of BV-2 cell and its NLRP3 inflammatory signaling pathway.
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