AIMC Topic: Cell Survival
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Magnetic Biohybrid Microrobot Multimers Based on Cells for Enhanced Targeted Drug Delivery.
ACS applied materials & interfaces
Jan 12, 2022
Magnetic micro-/nanorobots have been regarded as a promising platform for targeted drug delivery, and tremendous strategies have been developed in recent years. However, realizing precise and efficient drug delivery in vivo still remains challenging,...
A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy.
Bioorganic & medicinal chemistry
Nov 27, 2021
Colorectal cancer (CRC) is the third most detected cancer and the second foremost cause of cancer deaths in the world. Intervention targeting p53 provides potential therapeutic strategies, but thus far no p53-based therapy has been successfully trans...
Drug Discovery
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Dose-Response Relationship, Drug
Humans
Machine Learning
Colorectal Neoplasms
Molecular Docking Simulation
Tumor Suppressor Protein p53
Dihydroergotoxine
Cell Survival
Drug Screening Assays, Antitumor
Structure-Activity Relationship
Molecular Structure
Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals.
Toxicology letters
Nov 5, 2021
Although many neurotoxicity prediction studies of food additives have been developed, they are applicable in a qualitative way. We aimed to develop a novel prediction score that is described quantitatively and precisely. We examined cell viability, r...
Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival.
International journal of molecular sciences
Oct 5, 2021
Bisphenols are important environmental pollutants that are extensively studied due to different detrimental effects, while the molecular mechanisms behind these effects are less well understood. Like other environmental pollutants, bisphenols are bei...
Using molecular dynamics simulations to prioritize and understand AI-generated cell penetrating peptides.
Scientific reports
May 20, 2021
Cell-penetrating peptides have important therapeutic applications in drug delivery, but the variety of known cell-penetrating peptides is still limited. With a promise to accelerate peptide development, artificial intelligence (AI) techniques includi...
Magnetically Actuated Drug Delivery Helical Microrobot with Magnetic Nanoparticle Retrieval Ability.
ACS applied materials & interfaces
Apr 20, 2021
Therapeutic drug delivery microrobots capable of accurate targeting using an electromagnetic actuation (EMA) system are being developed. However, these drug delivery microrobots include a large number of magnetic nanoparticles (MNPs) for accurate EMA...
Automated evaluation of tumor spheroid behavior in 3D culture using deep learning-based recognition.
Biomaterials
Mar 22, 2021
Three-dimensional in vitro tumor models provide more physiologically relevant responses to drugs than 2D models, but the lack of proper evaluation indices and the laborious quantitation of tumor behavior in 3D have limited the use of 3D tumor models ...
Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.
Chemical biology & drug design
Dec 22, 2020
The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molec...
Phytochemical, antibacterial, antioxidant and cytoxicity investigation of .
Zeitschrift fur Naturforschung. C, Journal of biosciences
Dec 17, 2020
The phytochemical investigation of led to the isolation of 18 known compounds of which were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin () and soranjidiol...
Piperidine based 1,2,3-triazolylacetamide derivatives induce cell cycle arrest and apoptotic cell death in .
Journal of advanced research
Nov 10, 2020
The fungal pathogen , is a serious threat to public health and is associated with bloodstream infections causing high mortality particularly in patients with serious medical problems. As this pathogen is generally resistant to all the available clas...
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