AIMC Topic: Chemistry, Pharmaceutical
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The advantages of combination therapy on hypertension: development of immediate release perindopril-indapamide tablet and assessment of bioequivalence studies.
Pharmaceutical development and technology
Oct 13, 2015
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perind...
Hydrophilic Ionic Liquids as Ingredients of Gel-Based Dermal Formulations.
AAPS PharmSciTech
Oct 1, 2015
Ionic liquids (ILs) have several properties that offer many advantages in dermal drug delivery systems. Depending on the chemical structure, ILs can be used for protection against microorganisms, to enhance skin penetration, and as a solvent. In the ...
Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.
Journal of pharmaceutical and biomedical analysis
Aug 12, 2015
Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stab...
Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.
Drug development and industrial pharmacy
Jun 11, 2015
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solven...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Poloxamer
Polysorbates
Calcium Channel Blockers
Chemistry, Pharmaceutical
Delayed-Action Preparations
Nanomedicine
Technology, Pharmaceutical
Surface Properties
Lipids
Drug Carriers
Models, Chemical
Verapamil
Solubility
Computer Simulation
Polymers
Neural Networks, Computer
Nanoparticles
Algorithms
Kinetics
Particle Size
Recent advancements of Raman spectroscopy application in topical products.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Jul 1, 2025
Topical products have gained popularity in the recent years. Diverse formulation types, complex composition, and thermodynamically instable nature present great challenges in the formulation development of topical products. The analytical methods ava...
Harnessing Medicinal Chemical Intuition from Collective Intelligence.
Journal of medicinal chemistry
Jun 12, 2025
Over the past decade, collective intelligence, i.e., the intelligence that emerges from collective efforts, has transformed complex problem-solving and decision-making. In drug discovery, decision-making often relies on medicinal chemistry intuition....
Enhancing YOLOv8n with Mamba-like linear attention for defect detection and coating thickness analysis of irregular film tablet.
International journal of pharmaceutics
Jun 10, 2025
This study presents a real-time system that integrates deep learning and machine vision for defect detection and coating thickness measurement of irregularly shaped film-coated tablets. To overcome the accuracy and speed limitations of the traditiona...
Predicting the solubility of drugs in supercritical carbon dioxide using machine learning and atomic contribution.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Jun 1, 2025
The pharmaceutical sector is aware of supercritical CO (SC-CO) as a possible replacement for problematic organic solvents. Using a novel artificial intelligence (AI) strategy to predict drug solubility using the SC-CO system mathematically has been d...
Advancing Pharmaceutical Science with Artificial Neural Networks: A Review on Optimizing Drug Delivery Systems Formulation.
Current pharmaceutical design
Jan 1, 2025
Drug Delivery Systems (DDS) have been developed to address the challenges associated with traditional drug delivery methods. These DDS aim to improve drug administration, enhance patient compliance, reduce side effects, and optimize target therapy. T...
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