AIMC Topic: Chemistry, Pharmaceutical
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The advantages of combination therapy on hypertension: development of immediate release perindopril-indapamide tablet and assessment of bioequivalence studies.
Pharmaceutical development and technology
Oct 13, 2015
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perind...
Hydrophilic Ionic Liquids as Ingredients of Gel-Based Dermal Formulations.
AAPS PharmSciTech
Oct 1, 2015
Ionic liquids (ILs) have several properties that offer many advantages in dermal drug delivery systems. Depending on the chemical structure, ILs can be used for protection against microorganisms, to enhance skin penetration, and as a solvent. In the ...
Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.
Journal of pharmaceutical and biomedical analysis
Aug 12, 2015
Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stab...
Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.
Drug development and industrial pharmacy
Jun 11, 2015
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solven...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Delayed-Action Preparations
Poloxamer
Polysorbates
Surface Properties
Calcium Channel Blockers
Chemistry, Pharmaceutical
Neural Networks, Computer
Models, Chemical
Polymers
Kinetics
Nanomedicine
Technology, Pharmaceutical
Particle Size
Verapamil
Lipids
Solubility
Drug Carriers
Algorithms
Computer Simulation
Nanoparticles
Development of machine learning models for estimation of disintegration time on fast-disintegrating tablets.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Aug 1, 2025
The disintegration time for solid dosage oral formulations is directly influenced by diverse factors such as molecular properties, physical characteristics, excipient compositions, and formulation-specific attributes. This research addresses the chal...
Application of rheology to hot melt extrusion: Theory and practice.
International journal of pharmaceutics
Jul 25, 2025
Hot melt extrusion (HME) has become a key manufacturing method in the pharmaceutical industry for developing novel drug delivery systems, due to its solvent-free nature, ease of operation, and ability to achieve one-step molding and continuous proces...
Advancing Amorphous Solid Dispersions Design: Insights into Dissolution Kinetics via Thermodynamic Descriptor and Machine Learning.
Molecular pharmaceutics
Jul 7, 2025
Amorphous solid dispersions (ASD) are an effective strategy for enhancing the solubility and bioavailability of poorly soluble drugs. However, designing and optimizing ASD formulations often rely on extensive dissolution experiments without sufficie...
Recent advancements of Raman spectroscopy application in topical products.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Jul 1, 2025
Topical products have gained popularity in the recent years. Diverse formulation types, complex composition, and thermodynamically instable nature present great challenges in the formulation development of topical products. The analytical methods ava...
Harnessing Medicinal Chemical Intuition from Collective Intelligence.
Journal of medicinal chemistry
Jun 12, 2025
Over the past decade, collective intelligence, i.e., the intelligence that emerges from collective efforts, has transformed complex problem-solving and decision-making. In drug discovery, decision-making often relies on medicinal chemistry intuition....
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