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Cohort Studies

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Brain Age Analysis and Dementia Classification using Convolutional Neural Networks trained on Diffusion MRI: Tests in Indian and North American Cohorts.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Deep learning models based on convolutional neural networks (CNNs) have been used to classify Alzheimer's disease or infer dementia severity from T1-weighted brain MRI scans. Here, we examine the value of adding diffusion-weighted MRI (dMRI) as an in...

Effects of robot-assisted gait training within 1 week after stroke onset on degree of gait independence in individuals with hemiparesis: a propensity score-matched analysis in a single-center cohort study.

Journal of neuroengineering and rehabilitation
BACKGROUND: Robot-assisted gait training (RAGT) is an effective method for treating gait disorders in individuals with stroke. However, no previous studies have demonstrated the effectiveness of RAGT in individuals with acute stroke. This study aimed...

Machine learning approach on plasma proteomics identifies signatures associated with obesity in the KORA FF4 cohort.

Diabetes, obesity & metabolism
AIMS: This study investigated the role of plasma proteins in obesity to identify predictive biomarkers and explore underlying biological mechanisms.

Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study.

World journal of gastroenterology
BACKGROUND: The global prevalence of non-alcoholic steatohepatitis (NASH) and its associated risk of adverse outcomes, particularly in patients with advanced liver fibrosis, underscores the importance of early and accurate diagnosis.

A deep-learning retinal aging biomarker for cognitive decline and incident dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: The utility of retinal photography-derived aging biomarkers for predicting cognitive decline remains under-explored.

Developing and validating a prediction tool for cerebral amyloid angiopathy neuropathological severity.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Cerebral amyloid angiopathy (CAA) is a cerebrovascular condition, the severity of which can only be determined post mortem. Here, we developed machine learning models, the Florey CAA Score (FCAAS), to predict CAA severity (none/mild/mod...

Utilization of non-invasive ventilation before prehospital emergency anesthesia in trauma - a cohort analysis with machine learning.

Scandinavian journal of trauma, resuscitation and emergency medicine
BACKGROUND: For preoxygenation, German guidelines consider non-invasive ventilation (NIV) as a possible method in prehospital trauma care in the absence of aspiration, severe head or face injuries, unconsciousness, or patient non-compliance. As data ...

An interpretable machine learning approach for detecting psoriatic arthritis in a UK primary care psoriasis cohort using electronic health records from the Clinical Practice Research Datalink.

Annals of the rheumatic diseases
OBJECTIVES: Develop an interpretable machine learning model to detect patients with newly diagnosed psoriatic arthritis (PsA) in a cohort of psoriasis patients and identify important clinical indicators of PsA in primary care.

Determinants of ascending aortic morphology: cross-sectional deep learning-based analysis on 25 073 non-contrast-enhanced NAKO MRI studies.

European heart journal. Cardiovascular Imaging
AIMS: Understanding determinants of thoracic aortic morphology is crucial for precise diagnostics and therapeutic approaches. This study aimed to automatically characterize ascending aortic morphology based on 3D non-contrast-enhanced magnetic resona...