AIM: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are closely intertwined comorbidities that present significant clinical challenges due to the poorly understood pathophysiological mechanisms driving their coexistence. In this ...
Anticancer peptide (ACP) has emerged as potent therapeutic agents owing to its ability to selectively target cancer cells while minimising toxicity to healthy cells. However, the accurate computational prediction of ACP remains challenging because of...
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
BACKGROUND: Diabetic nephropathy (DN), affecting 30%-40% of diabetic patients, is the leading cause of end-stage renal disease worldwide. This study aims to identify diagnostic biomarkers and explore potential gene-metabolite interactions in DN patho...
Protein secondary structure prediction involves determining a protein's secondary structure from its primary amino acid sequence, serving as a critical step toward tertiary structure prediction. This, in turn, is essential for applications in drug de...
Structural data provides important information on the proteins' function. Recent development of advanced machine learning and artificial intelligence tools, such as AlphaFold, have led to an explosion of predicted protein structures. However, many of...
Interactions between proteins and lipids are crucial for numerous cellular processes. Some of the lipid interacting segments in protein sequences are intrinsically disordered regions (IDRs), which may gain secondary structures upon binding. We collec...
Interdisciplinary sciences, computational life sciences
Sep 1, 2025
The exploration of associations between circular RNAs (circRNAs) and diseases contributes to a deeper understanding of the pathogenesis of diseases. Many computational methods have been proposed for circRNA-disease associations identification. Howeve...
Chemotherapy is one of the most successful strategies for treating cancer. Unfortunately, up to 70 % of cancer survivors develop cognitive impairment during or after chemotherapy, which severely affects their quality of life. We first established a m...
Stress responses in biological systems arise from complex, dynamic interactions among genes, proteins, and metabolites. A thorough understanding of these responses requires examining not only changes in individual molecular components but also their ...
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