AIMC Topic: Delayed-Action Preparations
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Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone.
Pain medicine (Malden, Mass.)
Dec 14, 2015
OBJECTIVE: Evaluate the human abuse potential (HAP) of an experimental, microsphere-in-capsule formulation of extended-release oxycodone (oxycodone DETERx®) (herein "DETERx").
Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.
Pain medicine (Malden, Mass.)
Dec 14, 2015
OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the intranasal abuse potential ...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Poloxamer
Polysorbates
Surface Properties
Calcium Channel Blockers
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Carriers
Models, Chemical
Polymers
Kinetics
Verapamil
Solubility
Nanomedicine
Technology, Pharmaceutical
Computer Simulation
Nanoparticles
Particle Size
Lipids
Neural Networks, Computer
Algorithms
Identifying responders to gabapentin for the treatment of alcohol use disorder: an exploratory machine learning approach.
Alcohol and alcoholism (Oxford, Oxfordshire)
Mar 25, 2025
BACKGROUND: Gabapentin, an anticonvulsant medication, has been proposed as a treatment for alcohol use disorder (AUD). A multisite study tested gabapentin enacarbil extended-release (GE-XR; 600 mg/twice a day), a prodrug formulation, combined with a ...
Optimization of metronidazole SR buccal tablet for gingivitis using genetic algorithm.
Pakistan journal of pharmaceutical sciences
Nov 1, 2021
Gingivitis is a condition that needs sustained concentration of antibiotic locally over extended period of time. The current study aimed to formulate and evaluate the sustained and localized release of metronidazole (MTZ) as mucoadhesive buccal table...
Smart Micro/Nano-robotic Systems for Gene Delivery.
Current gene therapy
Jan 1, 2017
BACKGROUND: Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing...
Optimization of Melatonin Dissolution from Extended Release Matrices Using Artificial Neural Networking.
Current drug delivery
Jan 1, 2016
BACKGROUND: Efficacy of melatonin in treating sleep disorders has been demonstrated in numerous studies. Being with short half-life, melatonin needs to be formulated in extended-release tablets to prevent the fast drop of its plasma concentration. Ho...
Validation of an UV spectrophotometric assay for the quantification of polymyxin B in solid lipid nanoparticles.
Die Pharmazie
Nov 1, 2015
Polymyxins are efficient antibiotic drugs used for the treatment of Gram-negative bacterial infections. These compounds are not absorbed in the gastrointestinal tract and are responsible for serious toxicological effects. In order to enhance their th...
A self-powered kinesin-microtubule system for smart cargo delivery.
Nanoscale
Jan 7, 2015
A smart self-powered cargo delivery system that is composed of creatine phosphate kinase (CPK) microspheres, kinesins and microtubules is demonstrated. The CPK microsphere not only acts as an ATP generation and buffering system, but also as a carrier...
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