Sparse numerical datasets are dominant in fields such as applied mathematics, astronomy, finance, and healthcare, presenting challenges due to their high dimensionality and sparse distribution. The predominance of zero values complicates optimal feat...
BACKGROUND: It remains unclear whether certain individuals with type 2 diabetes (T2D) derive greater cardiovascular benefit from GLP-1 receptor agonists (GLP-1RAs). Here, we integrate individual-level data from cardiovascular outcome trials (CVOTs) a...
This study aims to identify risk factors associated with diabetic peripheral neuropathy (DPN) in patients with type 2 diabetesmellitus (T2DM) and to develop a predictive model to support clinical decision-making. A total of 1,001 patients with T2DM w...
Aldehyde compounds are significantly associated with diabetes mellitus. The metabolic profile of aldehydes can enhance understanding of the mechanisms underlying development of diabetes. This study employed a pair of stable isotope labeling (SIL) rea...
BACKGROUND: Cardiovascular disease remains the predominant cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Traditional risk models are limited in predictive accuracy. Pericoronary adipose tissue (PCAT), a novel i...
Type 2 diabetes mellitus (T2DM) is a severe metabolic disorder in which pancreatic injury plays a pivotal role in disease progression. Tanshinone IIA (TanIIA), a bioactive compound extracted from Salvia miltiorrhiza, has shown therapeutic potential i...
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that increases the risk of cardiovascular complications. The atherogenic index of plasma (AIP) is a risk marker for T2DM and cardiovascular disease on the basis of lipid profiles. T2DM an...
BACKGROUND: Deep learning (DL) models can quantify coronary artery calcification using non-gated chest CT scans. However, the prognostic value of a DL-based coronary artery calcium score (DL-CACS) for predicting major adverse cardiovascular events (M...
Type 2 diabetes mellitus remains a critical global health challenge, with rising incidence rates placing immense pressure on healthcare systems worldwide. This chronic metabolic disorder affects diverse populations, including the elderly and children...
While many mechanisms have been proposed to drive Alzheimer's disease, particularly the accumulation of amyloid plaques and hyperphosphorylation of tau proteins, emerging evidence suggests that they may be the byproducts of earlier damage rather than...
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