AIMC Topic: Disease Models, Animal

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Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Nature communications Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Treatment Outcome Disease Models, Animal Mice, Inbred C57BL Humans Intestinal Mucosa Reproducibility of Results Artificial Intelligence Animals Machine Learning Cohort Studies Inflammatory Bowel Diseases Mice Molecular Targeted Therapy Likelihood Functions Dextran Sulfate Colitis Organoids Mice, Knockout AMP-Activated Protein Kinases Multigene Family Gene Expression Regulation
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Hemopneumothorax detection through the process of artificial evolution - a feasibility study.

Military Medical Research Apr 25, 2021
BACKGROUND: Tension pneumothorax is one of the leading causes of preventable death on the battlefield. Current prehospital diagnosis relies on a subjective clinical impression complemented by a manual thoracic and respiratory examination. These techn...
Disease Models, Animal Feasibility Studies Stethoscopes Auscultation Artificial Intelligence Animals Swine Hemopneumothorax
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Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy.

Epilepsia Apr 5, 2021
OBJECTIVE: Improving the identification of the epileptogenic zone and associated seizure-spreading regions represents a significant challenge. Innovative brain-imaging modalities tracking neurovascular dynamics during seizures may provide new disease...
Brain Mapping Image Processing, Computer-Assisted Machine Learning Hippocampus Animals Epilepsy, Temporal Lobe Mice Male Multiparametric Magnetic Resonance Imaging Disease Models, Animal Mice, Inbred C57BL
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Prediction of cerebral perfusion pressure during CPR using electroencephalogram in a swine model of ventricular fibrillation.

The American journal of emergency medicine Feb 25, 2021
BACKGROUND: Measuring the quality of cardiopulmonary resuscitation (CPR) is important for improving outcomes in cardiac arrest. Cerebral perfusion pressure (CePP) could represent cerebral circulation during CPR, but it is difficult to measure non-inv...
Machine Learning Female Animals Swine Disease Models, Animal Electroencephalography Cross-Over Studies Cerebrovascular Circulation Cardiopulmonary Resuscitation Ventricular Fibrillation
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Proof of Concept for a Deep Learning Algorithm for Identification and Quantification of Key Microscopic Features in the Murine Model of DSS-Induced Colitis.

Toxicologic pathology Feb 12, 2021
Inflammatory bowel disease (IBD) is a complex disease which leads to life-threatening complications and decreased quality of life. The dextran sulfate sodium (DSS) colitis model in mice is known for rapid screening of candidate compounds. Efficacy as...
Mice Animals Disease Models, Animal Colon Mice, Inbred C57BL Artificial Intelligence Colitis Quality of Life Dextran Sulfate Deep Learning
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DeepACSON automated segmentation of white matter in 3D electron microscopy.

Communications biology Feb 10, 2021
Tracing the entirety of ultrastructures in large three-dimensional electron microscopy (3D-EM) images of the brain tissue requires automated segmentation techniques. Current segmentation techniques use deep convolutional neural networks (DCNNs) and r...
Image Interpretation, Computer-Assisted Cell Nucleus Microscopy, Electron White Matter Nerve Fibers, Myelinated Rats, Sprague-Dawley Disease Models, Animal Predictive Value of Tests Mitochondria Male Imaging, Three-Dimensional Rats Brain Injuries, Traumatic Artificial Intelligence Reproducibility of Results Animals
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Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.

Scientific reports Feb 9, 2021
Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore li...
Models, Neurological Injections, Spinal Spinal Cord Injuries Receptors, Tumor Necrosis Factor, Type I Animals Recombinant Proteins Rats Disease Models, Animal Rats, Long-Evans Artificial Intelligence Tumor Necrosis Factor-alpha Female
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Use of Machine Learning to Re-Assess Patterns of Multivariate Functional Recovery after Fluid Percussion Injury: Operation Brain Trauma Therapy.

Journal of neurotrauma Jan 13, 2021
Traumatic brain injury (TBI) is a leading cause of death and disability. Yet, despite immense research efforts, treatment options remain elusive. Translational failures in TBI are often attributed to the heterogeneity of the TBI population and limite...
Datasets as Topic Brain Injuries, Traumatic Disease Models, Animal Machine Learning Recovery of Function Animals Translational Research, Biomedical Rats
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Automated detection of mouse scratching behaviour using convolutional recurrent neural network.

Scientific reports Jan 12, 2021
Scratching is one of the most important behaviours in experimental animals because it can reflect itching and/or psychological stress. Here, we aimed to establish a novel method to detect scratching using deep neural network. Scratching was elicited ...
Dermatitis, Atopic Neural Networks, Computer Female Disease Models, Animal Animals Mice, Inbred BALB C Male Pruritus Mice Behavior, Animal Lysophospholipids
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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Haploinsufficiency Aortic Valve Disease Nitriles Small Molecule Libraries Disease Models, Animal Drug Discovery Aortic Valve Induced Pluripotent Stem Cells Humans Mice, Inbred C57BL RNA-Seq Drug Evaluation, Preclinical Receptor, Notch1 Machine Learning Calcinosis Gene Regulatory Networks Thiazoles Algorithms Aortic Valve Stenosis Mice Gene Expression Regulation Animals
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