AIMC Topic: Disease Models, Animal
Clear Filters Showing 11 to 20 of 328 articles
Human and animal models for studying hemorrhagic shock.
Scandinavian journal of trauma, resuscitation and emergency medicine
Jul 10, 2025
BACKGROUND: Studying the physiological response to severe hemorrhage remains challenging in real-world patients. Animal and human models mitigate some of the challenges by facilitating controlled studies on hemorrhagic shock. Here, we comment on exis...
TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.
Scientific reports
Jul 10, 2025
Intervertebral disc degeneration (IDD), a prevalent spinal condition linked to low back pain, has substantial genetic components, necessitating deeper understanding of its mechanisms. This study categorized nucleus pulposus cell (NPC) populations and...
The application and discovery of animal models in enterovirus research.
Archives of virology
Jul 8, 2025
Enterovirus infection remains a significant global public health challenge, causing severe diseases such as hand, foot, and mouth disease (HFMD) and meningitis. Given the current lack of effective broad-spectrum antiviral therapies, it is important t...
Predictive models of influenza A virus lethal disease yield insights from ferret respiratory tract and brain tissues.
Scientific reports
Jul 8, 2025
Collection of systemic tissues from influenza A virus (IAV)-infected ferrets at a fixed timepoint post-inoculation represents a frequent component of risk assessment activities to assess the capacity of IAV to replicate systemically. However, few stu...
Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's disease using diffusion imaging and tractography.
Journal of neural engineering
Jul 7, 2025
Parkinson's disease (PD) is a multifactorial, progressive neurodegenerative disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is characterized by degeneration of dopaminergic (DA) neurons in the midbrain which trig...
Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.
Molecular medicine (Cambridge, Mass.)
Jul 5, 2025
BACKGROUND: Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme,...
Clinical validation of AI assisted animal ultrasound models for diagnosis of early liver trauma.
Scientific reports
Jul 2, 2025
The study aimed to develop an AI-assisted ultrasound model for early liver trauma identification, using data from Bama miniature pigs and patients in Beijing, China. A deep learning model was created and fine-tuned with animal and clinical data, achi...
Machine learning-based model for behavioural analysis in rodents applied to the forced swim test.
Scientific reports
Jul 1, 2025
The Forced Swim Test (FST) is a widely used preclinical model for assessing antidepressant efficacy, studying stress response, and evaluating depressive-like behaviours in rodents. Over the last 10 years, more than 5500 scientific articles reporting ...
Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes.
Scientific reports
Jul 1, 2025
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic nerve head...
Artificial intelligence derived grading of mustard gas induced corneal injury and opacity.
Scientific reports
Jul 1, 2025
Artificial intelligence (AI) has emerged as a transformative tool in ophthalmology for disease diagnosis and prognosis. However, use of AI for assessing corneal damage due to chemical injury in live rabbits remains lacking. This study aimed to develo...
Don't Miss the Future of Medicine
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 32021
- Neural Networks, Computer 30231
- Algorithms 27405
- Deep Learning 26912
- Artificial Intelligence 24844
- Robotics 13389
- Image Processing, Computer-Assisted 9738
- Retrospective Studies 9346
- Magnetic Resonance Imaging 6347
- Reproducibility of Results 5670
- Tomography, X-Ray Computed 4866
- Support Vector Machine 4771
- Computational Biology 4333
- Brain 4129
- Computer Simulation 3935
Recent Journals
- Scientific reports 6800
- Sensors (Basel, Switzerland) 4794
- PloS one 4210
- Neural networks : the official journal of the International Neural Network Society 3026
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1916
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1378
- IEEE journal of biomedical and health informatics 1172
- Journal of chemical information and modeling 1066
- Nature communications 1047
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 874
- Journal of medical Internet research 864
- Briefings in bioinformatics 853