Acute Rheumatic Fever and Rheumatic Heart Disease (ARF/RHD) affect over 45 million people globally. ARF/RHD are autoimmune complications following group A streptococcal infections. Current diagnosis of ARF requires thorough medical examination, echoc...
Myocardial ischemia-reperfusion injury (MIRI) involves multifaceted pathogenic mechanisms, including inflammatory responses, immune dysregulation, and emerging forms of programmed cell death such as PANoptosis. However, the precise regulatory genes l...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most prevalent genetic kidney disorder. Animal preclinical studies are one of the main tools to study this disease, often through either 2D histology imaging for high-resolution analysis or ...
PURPOSE: Increasing evidence has indicated a role of oxidative stress in the pathogenesis of biliary atresia (BA). This study aimed to identify key oxidative stress-related biomarkers in BA and explore their therapeutic potential.
Liver fibrosis (LF) is a medical disorder caused by prolonged chronic liver injury, which, if left untreated, can progress to cirrhosis or liver cancer, posing significant risks to patient health. In recent years, the increase in liver diseases, incl...
Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammator...
Sleep-wake states bidirectionally interact with epilepsy and seizures, but the mechanisms are unknown. A barrier to comprehensive characterization and the study of mechanisms has been the difficulty of annotating large chronic recording datasets. To ...
This study presents a supervised machine learning approach using a Random Forest classifier to detect ischemia-reperfusion injury (IRI) in kidney tissue based on intravital two-photon microscopy data. A rodent model of unilateral renal IRI was used, ...
Studying locomotor activity in animal models is crucial for understanding physiological, behavioral, and pathological processes. This study aimed to develop an artificial intelligence-based tracking system called Goblotrop, designed to localize roden...
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle fiber degeneration and replacement by fibrous and adipose tissues, alongside significant vascular abnormalities. Traditional two-dimensional (2D) histological assessments provid...
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