Disease Models, Animal

Optimizing post-transplantation outcomes: the role of multi-omics, artificial intelligence, and animal models in addressing immunosuppression-associated hepatotoxicity.

International journal of surgery (London, England) Aug 1, 2024

Immunosuppressive Agents Immunosuppression Therapy Liver Transplantation Chemical and Drug Induced Liver Injury Animals Postoperative Complications Multiomics Disease Models, Animal Humans Artificial Intelligence

View on PubMed DOI

Machine learning approaches for influenza A virus risk assessment identifies predictive correlates using ferret model in vivo data.

Communications biology Aug 1, 2024

In vivo assessments of influenza A virus (IAV) pathogenicity and transmissibility in ferrets represent a crucial component of many pandemic risk assessment rubrics, but few systematic efforts to identify which data from in vivo experimentation are mo...

Influenza A virus Disease Models, Animal Ferrets Orthomyxoviridae Infections Machine Learning Algorithms Animals Risk Assessment

View on PubMed DOI

Multi-parametric MRI-based machine learning model for prediction of pathological grade of renal injury in a rat kidney cold ischemia-reperfusion injury model.

BMC medical imaging Jul 26, 2024

BACKGROUND: Renal cold ischemia-reperfusion injury (CIRI), a pathological process during kidney transplantation, may result in delayed graft function and negatively impact graft survival and function. There is a lack of an accurate and non-invasive t...

Machine Learning Animals Male Kidney Rats Multiparametric Magnetic Resonance Imaging Magnetic Resonance Imaging Rats, Sprague-Dawley Disease Models, Animal Reperfusion Injury

View on PubMed DOI

A personalized mRNA signature for predicting hypertrophic cardiomyopathy applying machine learning methods.

Scientific reports Jul 24, 2024

Hypertrophic cardiomyopathy (HCM) may lead to cardiac dysfunction and sudden death. This study was designed to develop a HCM signature applying bioinformatics and machine learning methods. Data of HCM and normal tissues were obtained from public data...

Gene Expression Profiling Transcriptome Gene Regulatory Networks Computational Biology RNA, Messenger Disease Models, Animal Zebrafish Cardiomyopathy, Hypertrophic Humans Machine Learning Animals

View on PubMed DOI

Amino acid metabolomics and machine learning-driven assessment of future liver remnant growth after hepatectomy in livers of various backgrounds.

Journal of pharmaceutical and biomedical analysis Jul 23, 2024

Accurate assessment of future liver remnant growth after partial hepatectomy (PH) in patients with different liver backgrounds is a pressing clinical issue. Amino acid (AA) metabolism plays a crucial role in liver regeneration. In this study, we comb...

Liver Regeneration Chromatography, High Pressure Liquid Tandem Mass Spectrometry Hepatectomy Mice Liver Cirrhosis Disease Models, Animal Mice, Inbred C57BL Metabolomics Liver Amino Acids Non-alcoholic Fatty Liver Disease Machine Learning Animals Male

View on PubMed DOI

Prediction of Left Ventricle Pressure Indices Via a Machine Learning Approach Combining ECG, Pulse Oximetry, and Cardiac Sounds: a Preclinical Feasibility Study.

Journal of cardiovascular translational research Jul 17, 2024

Heart failure (HF) is defined as the inability of the heart to meet body oxygen demand requiring an elevation in left ventricular filling pressures (LVP) to compensate. LVP increase can be assessed in the cardiac catheterization laboratory, but this ...

Stroke Volume Swine Electrocardiography Disease Models, Animal Machine Learning Animals Ventricular Function, Left Heart Rate Oximetry Swine, Miniature Heart Sounds Predictive Value of Tests Signal Processing, Computer-Assisted Feasibility Studies Heart Failure Phonocardiography Ventricular Pressure

View on PubMed DOI

Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks.

Scientific reports Jul 10, 2024

Assessment of spatial learning abilities is central to behavioral neuroscience and a useful tool for animal model validation and drug development. However, biases introduced by the apparatus, environment, or experimentalist represent a critical chall...

Disease Models, Animal Mice, Inbred C57BL Alzheimer Disease Behavior, Animal Maze Learning Neural Networks, Computer Female Spatial Learning Animals Male Mice

View on PubMed DOI

Identification of immune-related genes and small-molecule drugs in hypertension-induced left ventricular hypertrophy based on machine learning algorithms and molecular docking.

Frontiers in immunology Jun 27, 2024

BACKGROUND: Left ventricular hypertrophy (LVH) is a common consequence of hypertension and can lead to heart failure. The immune response plays an important role in hypertensive LVH; however, there is no comprehensive method to investigate the mechan...

Molecular Docking Simulation Machine Learning Animals Gene Expression Profiling Male Gene Regulatory Networks Mice Hypertension Disease Models, Animal Mice, Inbred C57BL Hypertrophy, Left Ventricular

View on PubMed DOI

Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning.

Frontiers in immunology Jun 27, 2024

BACKGROUND: Acetaminophen (APAP) is commonly used as an antipyretic analgesic. However, acetaminophen overdose may contribute to liver injury and even liver failure. Acetaminophen-induced liver injury (AILI) is closely related to mitochondrial oxidat...

Computational Biology Disease Models, Animal Machine Learning Transcriptome Mice, Inbred C57BL Copper Animals Protein Interaction Maps Liver Acetaminophen Male Mice Gene Expression Profiling Chemical and Drug Induced Liver Injury

View on PubMed DOI

Biohybrid microrobots regulate colonic cytokines and the epithelium barrier in inflammatory bowel disease.

Science robotics Jun 26, 2024

Cytokines have been identified as key contributors to the development of inflammatory bowel disease (IBD), yet conventional treatments often prove inadequate and carry substantial side effects. Here, we present an innovative biohybrid robotic system,...

Robotics Equipment Design Epithelium Nanoparticles Disease Models, Animal Mice, Inbred C57BL Intestinal Mucosa Male Colon Macrophages Mice Cytokines Humans Inflammatory Bowel Diseases Animals

View on PubMed DOI

AI Medical Compendium Topic

Explore the latest research on artificial intelligence and machine learning in medicine.

Optimizing post-transplantation outcomes: the role of multi-omics, artificial intelligence, and animal models in addressing immunosuppression-associated hepatotoxicity.

Machine learning approaches for influenza A virus risk assessment identifies predictive correlates using ferret model in vivo data.

Multi-parametric MRI-based machine learning model for prediction of pathological grade of renal injury in a rat kidney cold ischemia-reperfusion injury model.

A personalized mRNA signature for predicting hypertrophic cardiomyopathy applying machine learning methods.

Amino acid metabolomics and machine learning-driven assessment of future liver remnant growth after hepatectomy in livers of various backgrounds.

Prediction of Left Ventricle Pressure Indices Via a Machine Learning Approach Combining ECG, Pulse Oximetry, and Cardiac Sounds: a Preclinical Feasibility Study.

Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks.

Identification of immune-related genes and small-molecule drugs in hypertension-induced left ventricular hypertrophy based on machine learning algorithms and molecular docking.

Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning.

Biohybrid microrobots regulate colonic cytokines and the epithelium barrier in inflammatory bowel disease.

Popular Topics

Recent Journals