AIMC Topic: Disease Progression

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The Role of Autophagy and Cell Communication in COPD Progression: Insights from Bioinformatics and scRNA-seq.

COPD
Chronic obstructive pulmonary disease (COPD) is characterized by restricted airflow that leads to significant respiratory difficulties. This progressive disease often results in diminished pulmonary function and the onset of additional respiratory co...

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation-Based Morphometry Study.

Annals of neurology
OBJECTIVE: Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can improve i...

Towards realistic simulation of disease progression in the visual cortex with CNNs.

Scientific reports
Convolutional neural networks (CNNs) and mammalian visual systems share architectural and information processing similarities. We leverage these parallels to develop an in-silico CNN model simulating diseases affecting the visual system. This model a...

AI-facilitated home monitoring for cystic fibrosis exacerbations across pediatric and adult populations.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
BACKGROUND: AI-aided home stethoscopes offer the opportunity of continuous remote monitoring of cystic fibrosis (CF) patients, reducing the need for clinic visits.

Hybrid multi-modality multi-task learning for forecasting progression trajectories in subjective cognitive decline.

Neural networks : the official journal of the International Neural Network Society
While numerous studies strive to exploit the complementary potential of MRI and PET using learning-based methods, the effective fusion of the two modalities remains a tricky problem due to their inherently distinctive properties. In addition, current...

Deep learning for detecting and early predicting chronic obstructive pulmonary disease from spirogram time series.

NPJ systems biology and applications
Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung condition characterized by airflow obstruction. Current diagnostic methods primarily rely on identifying prominent features in spirometry (Volume-Flow time series) to detect COPD, but the...

Progression-Free Survival Prediction Performance of ChatGPT: Analysis With Real Life Data in Early and Locally Advanced Prostate Cancer.

The Prostate
OBJECTIVE: To evaluate the progression-free survival (PFS) time in patients with early-stage and locally advanced prostate cancer and to compare the estimates provided by ChatGPT with actual survival data.

A quantitatively interpretable model for Alzheimer's disease prediction using deep counterfactuals.

NeuroImage
Deep learning (DL) for predicting Alzheimer's disease (AD) has provided timely intervention in disease progression yet still demands attentive interpretability to explain how their DL models make definitive decisions. Counterfactual reasoning has rec...

Prediction of cognitive conversion within the Alzheimer's disease continuum using deep learning.

Alzheimer's research & therapy
BACKGROUND: Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment to optimal treatment modes. We aimed to develop a deep learning model to predict cognitive conversion to guide re-as...

Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning.

International immunopharmacology
BACKGROUND: Spinal cord injury (SCI) is a severe condition affecting the central nervous system. It is marked by a high disability rate and potential for death. Research has demonstrated that programmed cell death (PCD) plays a significant role in th...