AIMC Topic: DNA Methylation
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Multimodal analysis of cell-free DNA enhances differentiation of early-stage breast cancer from benign lesions and healthy individuals.
BMC biology
Aug 20, 2025
BACKGROUND: Breast cancer (BC) remains the second leading cause of cancer-related mortality among women worldwide. Liquid biopsy based on circulating tumor DNA (ctDNA) offers a promising noninvasive approach for early detection; however, differentiat...
Circulating epigenetic signatures classifying brain insulin resistance in humans.
Science translational medicine
Aug 6, 2025
Brain insulin action plays an important role in metabolic and cognitive health, but there is no biomarker available to assess brain insulin resistance in humans. Here, we developed a machine learning framework based on blood DNA methylation profiles ...
Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.
Nature communications
Jul 29, 2025
Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe th...
Interpretable graph Kolmogorov-Arnold networks for multi-cancer classification and biomarker identification using multi-omics data.
Scientific reports
Jul 29, 2025
The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph Kolmogorov-Arnold Network...
Prediction of MGMT methylation status in glioblastoma patients based on radiomics feature extracted from intratumoral and peritumoral MRI imaging.
Scientific reports
Jul 29, 2025
Assessing MGMT promoter methylation is crucial for determining appropriate glioblastoma therapy. Previous studies have focused on intratumoral regions, overlooking the peritumoral area. This study aimed to develop a radiomic model using MRI-derived f...
Advancements in DNA methylation technologies and their application in cancer diagnosis.
Epigenetics
Jul 28, 2025
DNA methylation is a common epigenetic modification that maintains the integrity of the DNA sequence while profoundly influencing gene expression and phenotypic variation. Aberrant DNA methylation has been associated with the onset and progression of...
Precision nutrition in epigenetic aging: SHAP-optimized machine learning identifies omega-3 constituent-specific associations with aging biomarkers.
Biogerontology
Jul 24, 2025
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA...
Distribution patterns of N6-methyladenine in the rye genome.
Scientific reports
Jul 18, 2025
N6-methyladenine (6 mA) has emerged as a potential epigenetic marker in eukaryotic genomes, yet its precise distribution patterns and biological functions in plant genomes are still not fully understood. In this study, we investigated the occurrence,...
Multi-tissue Methylation Analysis of Alzheimer's Disease: Insights into Pathways, Modules, and Key Genes.
Journal of molecular neuroscience : MN
Jul 16, 2025
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...
Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition.
Journal of translational medicine
Jul 4, 2025
BACKGROUND: Pancreatic cancer (PC) represents a highly heterogeneous malignancy with poor prognosis, where precise molecular subtyping facilitates comprehensive understanding of disease progression.
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