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Association of TLR 9 gene polymorphisms with remission in patients with rheumatoid arthritis receiving TNF-α inhibitors and development of machine learning models.

Scientific reports
Toll-like receptor (TLR)-4 and TLR9 are known to play important roles in the immune system, and several studies have shown their association with the development of rheumatoid arthritis (RA) and regulation of tumor necrosis factor alpha (TNF-α). Howe...

Global processing provides malignancy evidence complementary to the information captured by humans or machines following detailed mammogram inspection.

Scientific reports
The information captured by the gist signal, which refers to radiologists' first impression arising from an initial global image processing, is poorly understood. We examined whether the gist signal can provide complementary information to data captu...

Perception of yips among professional Japanese golfers: perspectives from a network modelled approach.

Scientific reports
'Yips' in golf is a complex spectrum of anxiety and movement-disorder that affects competitive sporting performance. With unclear etiology and high prevalence documented in western literature, the perception and management of this psycho-neuromuscula...

Predicting bloodstream infection outcome using machine learning.

Scientific reports
Bloodstream infections (BSI) are a main cause of infectious disease morbidity and mortality worldwide. Early prediction of BSI patients at high risk of poor outcomes is important for earlier decision making and effective patient stratification. We de...

Improved prediction of smoking status via isoform-aware RNA-seq deep learning models.

PLoS computational biology
Most predictive models based on gene expression data do not leverage information related to gene splicing, despite the fact that splicing is a fundamental feature of eukaryotic gene expression. Cigarette smoking is an important environmental risk fac...

Application of Medical Imaging Based on Deep Learning in the Treatment of Lumbar Degenerative Diseases and Osteoporosis with Bone Cement Screws.

Computational and mathematical methods in medicine
OBJECTIVE: To explore the application value of magnetic resonance spectroscopy (MRS) and GSI-energy spectrum electronic computed tomography (CT) medical imaging based on the deep convolutional neural network (CNN) in the treatment of lumbar degenerat...

Artificial image objects for classification of breast cancer biomarkers with transcriptome sequencing data and convolutional neural network algorithms.

Breast cancer research : BCR
BACKGROUND: Transcriptome sequencing has been broadly available in clinical studies. However, it remains a challenge to utilize these data effectively for clinical applications due to the high dimension of the data and the highly correlated expressio...

Image quality assessment of pediatric chest and abdomen CT by deep learning reconstruction.

BMC medical imaging
BACKGROUND: Efforts to reduce the radiation dose have continued steadily, with new reconstruction techniques. Recently, image denoising algorithms using artificial neural networks, termed deep learning reconstruction (DLR), have been applied to CT im...

Predicting microvascular invasion in hepatocellular carcinoma: a deep learning model validated across hospitals.

Cancer imaging : the official publication of the International Cancer Imaging Society
BACKGROUND: The accuracy of estimating microvascular invasion (MVI) preoperatively in hepatocellular carcinoma (HCC) by clinical observers is low. Most recent studies constructed MVI predictive models utilizing radiological and/or radiomics features ...