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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal of translational medicine
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...

Mobile health apps for skin cancer triage in the general population: a qualitative study on healthcare providers' perspectives.

BMC cancer
BACKGROUND: Mobile health (mHealth) applications (apps) integrated with artificial intelligence for skin cancer triage are increasingly available to the general public. Nevertheless, their actual uptake is limited. Although endorsement by healthcare ...

Exploring machine learning algorithms to predict short birth intervals and identify its determinants among reproductive-age women in East Africa.

BMC pregnancy and childbirth
BACKGROUND: The occurrence of short birth intervals among reproductive-age women in East Africa is a critical public health issue, contributing to maternal and child health risks. Identifying the key factors that predict short birth intervals can hel...

Construction and validation of a predictive model for suicidal ideation in non-psychiatric elderly inpatients.

BMC geriatrics
BACKGROUND: Suicide poses a substantial public health challenge globally, with the elderly population being particularly vulnerable. Research into suicide risk factors among elderly inpatients with non-psychiatric disorders remains limited. This inve...

Splenic and portal venous flow associated with frailty and sarcopenia in older outpatients with cardiovascular disease.

BMC geriatrics
BACKGROUND: Older patients with cardiovascular disease often experience frailty and sarcopenia. We evaluated whether a reduced blood flow in the splenic and portal vein is associated with frailty and sarcopenia in older patients with cardiovascular d...

Construction of disability risk prediction model for the elderly based on machine learning.

Scientific reports
The study aimed to develop a predictive model using machine learning algorithms, providing healthcare professionals with a novel tool for assessing disability risk in older adults. Data from the 2018 and 2020 waves of the China Health and Retirement ...

Machine learning-based prediction of 90-day prognosis and in-hospital mortality in hemorrhagic stroke patients.

Scientific reports
This study aims to predict hemorrhagic stroke outcomes, including 90-day prognosis and in-hospital mortality, using machine learning models and SHapley Additive exPlanations (SHAP) analysis. Data were collected from a national Stroke Registry from Ja...

Multiparameter MRI-based model integrating radiomics and deep learning for preoperative staging of laryngeal squamous cell carcinoma.

Scientific reports
The accurate preoperative staging of laryngeal squamous cell carcinoma (LSCC) provides valuable guidance for clinical decision-making. The objective of this study was to establish a multiparametric MRI model using radiomics and deep learning (DL) to ...

Accurate multi-category student performance forecasting at early stages of online education using neural networks.

Scientific reports
The ability to accurately predict and analyze student performance in online education, both at the outset and throughout the semester, is vital. Most of the published studies focus on binary classification (Fail or Pass) but there is still a signific...

Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.

Scientific reports
Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure to reduce the global incidence of HBV. The duration of protection after HBV vaccination is still cont...