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Machine learning can identify newly diagnosed patients with CLL at high risk of infection.

Nature communications
Infections have become the major cause of morbidity and mortality among patients with chronic lymphocytic leukemia (CLL) due to immune dysfunction and cytotoxic CLL treatment. Yet, predictive models for infection are missing. In this work, we develop...

Improving the detection of autism spectrum disorder by combining structural and functional MRI information.

NeuroImage. Clinical
Autism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase i...

Deep learning-based automated speech detection as a marker of social functioning in late-life depression.

Psychological medicine
BACKGROUND: Late-life depression (LLD) is associated with poor social functioning. However, previous research uses bias-prone self-report scales to measure social functioning and a more objective measure is lacking. We tested a novel wearable device ...

Application of data mining in a cohort of Italian subjects undergoing myocardial perfusion imaging at an academic medical center.

Computer methods and programs in biomedicine
INTRODUCTION: Coronary artery disease (CAD) is still one of the primary causes of death in the developed countries. Stress single-photon emission computed tomography is used to evaluate myocardial perfusion and ventricular function in patients with s...

Preliminary experience with an image-free handheld robot for total knee arthroplasty: 77 cases compared with a matched control group.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
BACKGROUND: Achieving an optimal limb alignment is an important factor affecting the long-term survival of total knee arthroplasty (TKA). This is the first study to look at the limb alignment and orientation of components in TKA using a novel image-f...

Upstaging to pT3a disease in patients undergoing robotic partial nephrectomy for cT1 kidney cancer: Outcomes and predictors from a multi-institutional dataset.

Urologic oncology
OBJECTIVES: Surgically treated clinical T1 (cT1) kidney cancer has in general a good prognosis, but there is a risk of upstaging that can potentially jeopardize the oncological outcomes after partial nephrectomy (PN). Aim of this study is to analyze ...

Adaptive Ankle Resistance from a Wearable Robotic Device to Improve Muscle Recruitment in Cerebral Palsy.

Annals of biomedical engineering
Individuals with cerebral palsy can have weak and poorly coordinated ankle plantar flexor muscles that contribute to inefficient walking patterns. Previous studies attempting to improve plantar flexor function have had inconsistent effects on mobilit...

Competitive Learning in a Spiking Neural Network: Towards an Intelligent Pattern Classifier.

Sensors (Basel, Switzerland)
One of the modern trends in the design of human-machine interfaces (HMI) is to involve the so called spiking neuron networks (SNNs) in signal processing. The SNNs can be trained by simple and efficient biologically inspired algorithms. In particular,...