AIMC Topic: Ferroptosis
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NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes.
Cell biology and toxicology
Dec 21, 2024
BACKGROUND: Globally, pre-eclampsia (PE) poses a major threat to the health and survival of pregnant women and fetuses, contributing significantly to morbidity and mortality. Recent studies suggest a pathological link between PE and ferroptosis. We a...
Machine Learning-Engineered Nanozyme System for Synergistic Anti-Tumor Ferroptosis/Apoptosis Therapy.
Small (Weinheim an der Bergstrasse, Germany)
Dec 16, 2024
Nanozymes with multienzyme-like activity have sparked significant interest in anti-tumor therapy via responding to the tumor microenvironment (TME). However, the consequent induction of protective autophagy substantially compromises the therapeutic e...
Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Frontiers in immunology
Dec 13, 2024
BACKGROUND: Thyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue. Ferroptosis is a form of programm...
Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm.
Frontiers in immunology
Dec 11, 2024
BACKGROUND: Abdominal aortic aneurysm (AAA) is a serious life-threatening vascular disease, and its ferroptosis/cuproptosis markers have not yet been characterized. This study was aiming to identify markers associated with ferroptosis/cuproptosis in ...
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration.
Apoptosis : an international journal on programmed cell death
Dec 4, 2024
Intervertebral disc degeneration (IVDD) is intricately associated with various forms of programmed cell death (PCD). Identifying key PCD types and associated genes is essential for understanding the molecular mechanisms underlying IVDD and discoverin...
Ferroptosis-related biomarkers for adamantinomatous craniopharyngioma treatment: conclusions from machine learning techniques.
Frontiers in endocrinology
Nov 13, 2024
INTRODUCTION: Adamantinomatous craniopharyngioma (ACP) is difficult to cure completely and prone to recurrence after surgery. Ferroptosis as an iron-dependent programmed cell death, may be a critical process in ACP. The study aimed to screen diagnost...
Identification of ferroptosis-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches.
International journal of biological macromolecules
Oct 31, 2024
Ferroptosis has emerged as a critical mechanism in the development and progression of various tumors, particularly diffuse large B-cell lymphoma (DLBCL). However, the thorough characterization of ferroptosis-related genes in DLBCL remains inadequatel...
Screening COPD-Related Biomarkers and Traditional Chinese Medicine Prediction Based on Bioinformatics and Machine Learning.
International journal of chronic obstructive pulmonary disease
Sep 24, 2024
PURPOSE: To employ bioinformatics and machine learning to predict the characteristics of immune cells and genes associated with the inflammatory response and ferroptosis in chronic obstructive pulmonary disease (COPD) patients and to aid in the devel...
Drugs, Chinese Herbal
Genetic Markers
Phenotype
Humans
Ferroptosis
Molecular Docking Simulation
Machine Learning
Biomarkers
MicroRNAs
Genetic Predisposition to Disease
Gene Expression Profiling
Pulmonary Disease, Chronic Obstructive
Predictive Value of Tests
Computational Biology
Transcriptome
Lung
Mendelian Randomization Analysis
Databases, Genetic
Gene Regulatory Networks
Medicine, Chinese Traditional
Developing a machine learning-based prognosis and immunotherapeutic response signature in colorectal cancer: insights from ferroptosis, fatty acid dynamics, and the tumor microenvironment.
Frontiers in immunology
Jul 15, 2024
INSTRUCTION: Colorectal cancer (CRC) poses a challenge to public health and is characterized by a high incidence rate. This study explored the relationship between ferroptosis and fatty acid metabolism in the tumor microenvironment (TME) of patients ...
Investigation of ferroptosis-associated molecular subtypes and immunological characteristics in lupus nephritis based on artificial neural network learning.
Arthritis research & therapy
Jul 3, 2024
BACKGROUND: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) with poor treatment outcomes. The role and underlying mechanisms of ferroptosis in LN remain largely unknown. We aimed to explore ferroptosis-related mole...
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