AIMC Topic: Gene Expression Profiling

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Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes.

Frontiers in immunology
OBJECTIVE: Subarachnoid hemorrhage (SAH) and tumorigenesis share numerous biological complexities; nevertheless, the specific gene expression profiles and underlying mechanisms remain poorly understood. This study aims to identify differentially expr...

Prediction of gene expression-based breast cancer proliferation scores from histopathology whole slide images using deep learning.

BMC cancer
BACKGROUND: In breast cancer, several gene expression assays have been developed to provide a more personalised treatment. This study focuses on the prediction of two molecular proliferation signatures: an 11-gene proliferation score and the MKI67 pr...

Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm.

Frontiers in immunology
BACKGROUND: Abdominal aortic aneurysm (AAA) is a serious life-threatening vascular disease, and its ferroptosis/cuproptosis markers have not yet been characterized. This study was aiming to identify markers associated with ferroptosis/cuproptosis in ...

Establishment of multiple machine learning prognostic model for gene differences between primary tumors and lymph nodes in luminal breast cancer.

Breast cancer research and treatment
BACKGROUND: This study aimed to explore the correlation between primary tumors (PT) and paired metastatic lymph nodes (LN) and to develop a predictive model to provide evidence for forecasting patient prognoses.

An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning.

Biology direct
BACKGROUND: MicroRNAs (miRNAs) have shown potential as diagnostic biomarkers for myocardial infarction (MI) due to their early dysregulation and stability in circulation after MI. Moreover, they play a crucial role in regulating adaptive and maladapt...

Enhancing Spatial Domain Identification in Spatially Resolved Transcriptomics Using Graph Convolutional Networks With Adaptively Feature-Spatial Balance and Contrastive Learning.

IEEE/ACM transactions on computational biology and bioinformatics
Recent advancements in spatially transcriptomics (ST) technologies have enabled the comprehensive measurement of gene expression profiles while preserving the spatial information of cells. Combining gene expression profiles and spatial information ha...

Improved Fuzzy Cognitive Maps for Gene Regulatory Networks Inference Based on Time Series Data.

IEEE/ACM transactions on computational biology and bioinformatics
Microarray data provide lots of information regarding gene expression levels. Due to the large amount of such data, their analysis requires sufficient computational methods for identifying and analyzing gene regulation networks; however, researchers ...

Simple and effective embedding model for single-cell biology built from ChatGPT.

Nature biomedical engineering
Large-scale gene-expression data are being leveraged to pretrain models that implicitly learn gene and cellular functions. However, such models require extensive data curation and training. Here we explore a much simpler alternative: leveraging ChatG...