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Gene Expression Regulation, Neoplastic

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Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro.

Journal of cancer research and therapeutics
BACKGROUND: Hepatocellular carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. Norcantharidin (NCTD), the demethylated analog of cantharidin derived from a traditional Chinese me...

Employing social network analysis for disease biomarker detection.

International journal of data mining and bioinformatics
Detection of disease biomarkers in general and cancer biomarkers in particular is an important task which has received considerable attention in the area of in silico genomic experiments. We describe a new approach for detecting cancer biomarkers bas...

Regularised extreme learning machine with misclassification cost and rejection cost for gene expression data classification.

International journal of data mining and bioinformatics
The main purpose of traditional classification algorithms on bioinformatics application is to acquire better classification accuracy. However, these algorithms cannot meet the requirement that minimises the average misclassification cost. In this pap...

Neural networks and Fuzzy clustering methods for assessing the efficacy of microarray based intrinsic gene signatures in breast cancer classification and the character and relations of identified subtypes.

Methods in molecular biology (Clifton, N.J.)
In the classification of breast cancer subtypes using microarray data, hierarchical clustering is commonly used. Although this form of clustering shows basic cluster patterns, more needs to be done to investigate the accuracy of clusters as well as t...