AIMC Topic: Head and Neck Neoplasms

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Identification of a gene score related to antigen processing and presentation machinery for predicting prognosis in head and neck squamous cell carcinoma and its potential implications for immunotherapy.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico Dec 31, 2024
BACKGROUND: Despite its crucial role in immune surveillance and cell survival of tumors, the significance of MHC antigen processing and presentation machinery (APM) is still not fully understood in head and neck squamous cell carcinoma (HNSCC). We so...
Antigen Presentation Prognosis Female Biomarkers, Tumor Humans Squamous Cell Carcinoma of Head and Neck Machine Learning Head and Neck Neoplasms Male Immunotherapy
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Integrating immune multi-omics and machine learning to improve prognosis, immune landscape, and sensitivity to first- and second-line treatments for head and neck squamous cell carcinoma.

Scientific reports Dec 28, 2024
In recent years, immune checkpoint inhibitors (ICIs) has emerged as a fundamental component of the standard treatment regimen for patients with head and neck squamous cell carcinoma (HNSCC). However, accurately predicting the treatment effectiveness ...
Multiomics Gene Expression Regulation, Neoplastic Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms DNA Methylation Humans Male Prognosis Immune Checkpoint Inhibitors Machine Learning Female Immunotherapy Algorithms Biomarkers, Tumor
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Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma.

CPT: pharmacometrics & systems pharmacology Dec 25, 2024
We employed a mechanistic learning approach, integrating on-treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post-progression survival (PPS)-the duration from the time of document...
Humans Treatment Outcome Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms Cetuximab Male Middle Aged Machine Learning Antineoplastic Combined Chemotherapy Protocols Female Aged
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Automated treatment planning with deep reinforcement learning for head-and-neck (HN) cancer intensity modulated radiation therapy (IMRT).

Physics in medicine and biology Dec 24, 2024
To develop a deep reinforcement learning (DRL) agent to self-interact with the treatment planning system to automatically generate intensity modulated radiation therapy (IMRT) treatment plans for head-and-neck (HN) cancer with consistent organ-at-ris...
Humans Deep Learning Head and Neck Neoplasms Organs at Risk Radiotherapy, Intensity-Modulated Radiotherapy Planning, Computer-Assisted Automation Radiotherapy Dosage
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CT-based clinical-radiomics model to predict progression and drive clinical applicability in locally advanced head and neck cancer.

European radiology Dec 20, 2024
BACKGROUND: Definitive chemoradiation is the primary treatment for locally advanced head and neck carcinoma (LAHNSCC). Optimising outcome predictions requires validated biomarkers, since TNM8 and HPV could have limitations. Radiomics may enhance risk...
Female Aged Adult Humans Tomography, X-Ray Computed Middle Aged Disease Progression Head and Neck Neoplasms Sensitivity and Specificity Chemoradiotherapy Radiomics Male
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Machine-learning derived identification of prognostic signature to forecast head and neck squamous cell carcinoma prognosis and drug response.

Frontiers in immunology Dec 19, 2024
INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC), a highly heterogeneous malignancy is often associated with unfavorable prognosis. Due to its unique anatomical position and the absence of effective early inspection methods, surgical inter...
Middle Aged Female Squamous Cell Carcinoma of Head and Neck Antineoplastic Agents Humans Gene Expression Profiling Head and Neck Neoplasms Biomarkers, Tumor Machine Learning Male Prognosis
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Integrating machine learning, bioinformatics and experimental verification to identify a novel prognostic marker associated with tumor immune microenvironment in head and neck squamous carcinoma.

Frontiers in immunology Dec 10, 2024
Head and neck squamous carcinoma (HNSC), characterized by a high degree of malignancy, develops in close association with the tumor immune microenvironment (TIME). Therefore, identifying effective targets related to HNSC and TIME is of paramount impo...
Biomarkers, Tumor Gene Expression Profiling Humans Computational Biology Databases, Genetic Machine Learning Gene Expression Regulation, Neoplastic Prognosis Squamous Cell Carcinoma of Head and Neck Tumor Microenvironment Head and Neck Neoplasms
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Quality of Information Provided by Artificial Intelligence Chatbots Surrounding the Reconstructive Surgery for Head and Neck Cancer: A Comparative Analysis Between ChatGPT4 and Claude2.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Dec 4, 2024
INTRODUCTION: Artificial Intelligences (AIs) are changing the way information is accessed and consumed globally. This study aims to evaluate the information quality provided by AIs ChatGPT4 and Claude2 concerning reconstructive surgery for head and n...
Generative Artificial Intelligence Head and Neck Neoplasms Plastic Surgery Procedures Artificial Intelligence Surveys and Questionnaires Humans
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Assessing population-based to personalized planning strategies for head and neck adaptive radiotherapy.

Journal of applied clinical medical physics Dec 3, 2024
PURPOSE: Optimal head-and-neck cancer (HNC) treatment planning requires accurate and feasible planning goals to meet dosimetric constraints and generate robust online adaptive treatment plans. A new x-ray-based adaptive radiotherapy (ART) treatment p...
Radiotherapy, Intensity-Modulated Precision Medicine Retrospective Studies Head and Neck Neoplasms Organs at Risk Radiotherapy Planning, Computer-Assisted Radiotherapy Dosage Humans Artificial Intelligence Algorithms
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Deep learning based super-resolution for CBCT dose reduction in radiotherapy.

Medical physics Dec 3, 2024
BACKGROUND: Cone-beam computed tomography (CBCT) is a crucial daily imaging modality in image-guided and adaptive radiotherapy. However, the use of ionizing radiation in CBCT imaging increases the risk of secondary cancers, which is particularly conc...
Cone-Beam Computed Tomography Image Processing, Computer-Assisted Head and Neck Neoplasms Humans Deep Learning Radiation Dosage Radiotherapy Dosage Radiotherapy, Image-Guided
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