AIMC Topic: Hep G2 Cells

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Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway.

Journal of ethnopharmacology Oct 6, 2021
ETHNOPHARMACOLOGICAL RELEVANCE: Mulberry leaves have been used as traditional hypoglycemic medicine-food plant for thousand years in China. According to traditional Chinese medicine theory, type 2 diabetes mellitus (T2DM) belongs to the category of X...
NF-kappa B p38 Mitogen-Activated Protein Kinases Polysaccharides Morus Alkaloids 3T3-L1 Cells Glycation End Products, Advanced Hypoglycemic Agents Receptor for Advanced Glycation End Products Hep G2 Cells Plant Leaves Flavonoids Humans Male Diabetes Mellitus, Experimental Animals Diabetes Mellitus, Type 2 Mice Plant Extracts
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Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs.

Nature communications Mar 25, 2021
Artificial intelligence and machine learning (ML) promise to transform cancer therapies by accurately predicting the most appropriate therapies to treat individual patients. Here, we present an approach, named Drug Ranking Using ML (DRUML), which use...
Humans Machine Learning Prognosis Cell Proliferation Neoplasms Hep G2 Cells Antineoplastic Agents Drug Screening Assays, Antitumor Cell Line, Tumor Leukemia Computational Biology Cytarabine Proteomics
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Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments.

Nature communications Dec 7, 2020
Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit fluorescence microscopy's utility. Recently, it has been shown t...
Time-Lapse Imaging Cell Compartmentation Reproducibility of Results Cytoplasm Animals Microscopy, Phase-Contrast Humans Cell Line, Tumor Intracellular Space CHO Cells Artificial Intelligence Hep G2 Cells Microscopy, Interference Algorithms Cricetulus Microscopy, Fluorescence Cell Nucleus Cricetinae
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Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.

Archives of toxicology Jun 12, 2020
Accurate prediction of drug- and chemical-induced hepatotoxicity remains to be a problem for pharmaceutical companies as well as other industries and regulators. The goal of the current study was to develop an in vitro/in silico method for the rapid ...
Humans Machine Learning Phenotype Risk Assessment Microscopy, Fluorescence Cellular Senescence Cell Death Hepatocytes High-Throughput Screening Assays Image Processing, Computer-Assisted Hep G2 Cells Dose-Response Relationship, Drug DNA Damage Actin Cytoskeleton Proto-Oncogene Mas Toxicity Tests Transcription Factor RelA Chemical and Drug Induced Liver Injury Primary Cell Culture
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Revealing cytotoxic substructures in molecules using deep learning.

Journal of computer-aided molecular design Apr 16, 2020
In drug development, late stage toxicity issues of a compound are the main cause of failure in clinical trials. In silico methods are therefore of high importance to guide the early design process to reduce time, costs and animal testing. Technical a...
Small Molecule Libraries Models, Biological Cytotoxins HEK293 Cells Toxicology Humans Neural Networks, Computer Software Computer-Aided Design Drug Design Drug Discovery Deep Learning Hep G2 Cells Cell Survival
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UPLC-ESI-MS/MS based identification and antioxidant, antibacterial, cytotoxic activities of aqueous extracts from storey onion (Allium cepa L. var. proliferum Regel).

Food research international (Ottawa, Ont.) Dec 30, 2019
Storey onion (Allium cepa L. var. proliferum Regel) is a variety of onion commonly grown in northern China that has not been researched in detail. This study aimed to identify the chemical compositions of storey onion aqueous extracts by UPLC-ESI-MS/...
Free Radicals Onions Humans Yeasts Hep G2 Cells Anti-Bacterial Agents Antineoplastic Agents, Phytogenic Bacteria Chromatography, Liquid Antioxidants Tandem Mass Spectrometry Aspergillus niger
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Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line.

Analytical cellular pathology (Amsterdam) Aug 4, 2019
Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therapy. Plant-derived compounds acting as anticancer agents can induce apoptosis by targeting several signaling pathways. ...
Humans Hep G2 Cells Lactones Liver Neoplasms Down-Regulation Carcinoma, Hepatocellular Up-Regulation Gene Ontology RNA, Messenger Gene Expression Regulation, Neoplastic
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Deep-learning augmented RNA-seq analysis of transcript splicing.

Nature methods Mar 25, 2019
A major limitation of RNA sequencing (RNA-seq) analysis of alternative splicing is its reliance on high sequencing coverage. We report DARTS (https://github.com/Xinglab/DARTS), a computational framework that integrates deep-learning-based predictions...
Gene Expression Regulation K562 Cells RNA Splicing Exons Alternative Splicing Bayes Theorem Signal Processing, Computer-Assisted RNA High-Throughput Nucleotide Sequencing Humans Algorithms Reproducibility of Results Gene Expression Profiling Deep Learning Sequence Analysis, RNA Epigenomics Hep G2 Cells Models, Statistical
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Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells.

Lipids Feb 1, 2019
Increasing apolipoprotein A-I (apoA-I), the predominant protein of high-density lipoprotein (HDL) particles, has favorable effects on atherogenic risk factors. Here, we investigated the effects of peroxisome proliferator-activated receptor α (PPARα) ...
PPAR alpha Humans Hep G2 Cells Cymarine Biological Products Dicarboxylic Acids Cell Survival Apolipoprotein A-I HEK293 Cells
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Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma.

Bioorganic chemistry Dec 31, 2018
Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a pri...
Molecular Docking Simulation Antineoplastic Agents Liver Neoplasms Carcinoma, Hepatocellular Cell Proliferation ErbB Receptors Hep G2 Cells Phthalazines Humans Drug Screening Assays, Antitumor Protein Kinase Inhibitors Cisplatin Doxorubicin
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