AIMC Topic: Hepatitis C

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Association of Individual and Community Factors With Hepatitis C Infections Among Pregnant People and Newborns.

JAMA health forum Oct 29, 2021
IMPORTANCE: The opioid crisis has increasingly affected pregnant people and infants. Hepatitis C virus (HCV) infections, a known complication of opioid use, grew in parallel with opioid-related complications; however, the literature informing individ...
Hepatitis C Opioid-Related Disorders Infant, Newborn Humans Cross-Sectional Studies Retrospective Studies United States Pregnancy Analgesics, Opioid Female Hepacivirus
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StackHCV: a web-based integrative machine-learning framework for large-scale identification of hepatitis C virus NS5B inhibitors.

Journal of computer-aided molecular design Oct 8, 2021
Fast and accurate identification of inhibitors with potency against HCV NS5B polymerase is currently a challenging task. As conventional experimental methods is the gold standard method for the design and development of new HCV inhibitors, they often...
Humans Hepacivirus Hepatitis C Enzyme Inhibitors Viral Nonstructural Proteins RNA-Dependent RNA Polymerase Machine Learning Algorithms Antiviral Agents Support Vector Machine Internet
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Domain-Scan: Combinatorial Sero-Diagnosis of Infectious Diseases Using Machine Learning.

Frontiers in immunology Feb 10, 2021
The presence of pathogen-specific antibodies in an individual's blood-sample is used as an indication of previous exposure and infection to that specific pathogen (e.g., virus or bacterium). Measurement of the diagnostic antibodies is routinely achie...
DNA, Recombinant HIV Envelope Protein gp160 Hepatitis C Antigens High-Throughput Nucleotide Sequencing DNA Barcoding, Taxonomic Base Sequence Polymerase Chain Reaction Hepatitis C Antibodies HIV Core Protein p24 Genetic Vectors HIV Antibodies AIDS Serodiagnosis Epitopes Antigen-Antibody Reactions Amino Acid Sequence Oligonucleotides Hepatitis C Serologic Tests Humans Communicable Diseases Machine Learning HIV Infections Peptide Library Peptide Fragments
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PeptiDesCalculator: Software for computation of peptide descriptors. Definition, implementation and case studies for 9 bioactivity endpoints.

Proteins Sep 17, 2020
We present a novel Java-based program denominated PeptiDesCalculator for computing peptide descriptors. These descriptors include: redefinitions of known protein parameters to suite the peptide domain, generalization schemes for the global descriptio...
Pseudomonas aeruginosa Hepatitis C Protein Stability Peptide Mapping Antiviral Agents Support Vector Machine Candida albicans Antifungal Agents Listeria monocytogenes Humans Neural Networks, Computer Software Anti-Bacterial Agents Neoplasms Peptides Antineoplastic Agents HIV Infections
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Finding undiagnosed patients with hepatitis C infection: an application of artificial intelligence to patient claims data.

Scientific reports Jun 29, 2020
Hepatitis C virus (HCV) remains a significant public health challenge with approximately half of the infected population untreated and undiagnosed. In this retrospective study, predictive models were developed to identify undiagnosed HCV patients usi...
Mass Screening Hepatitis C Artificial Intelligence Algorithms Databases, Factual Retrospective Studies Models, Theoretical Humans
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Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals.

PloS one Jan 10, 2020
Several European countries have established criteria for prioritising initiation of treatment in patients infected with the hepatitis C virus (HCV) by grouping patients according to clinical characteristics. Based on neural network techniques, our ob...
Machine Learning Decision Support Techniques Prospective Studies Female Aged Humans Neural Networks, Computer Antiviral Agents Follow-Up Studies Coinfection HIV Hepacivirus Young Adult Adult Male Middle Aged Adolescent Hepatitis C AIDS-Related Opportunistic Infections Spain
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Targeting HIV/HCV Coinfection Using a Machine Learning-Based Multiple Quantitative Structure-Activity Relationships (Multiple QSAR) Method.

International journal of molecular sciences Jul 22, 2019
Human immunodeficiency virus type-1 and hepatitis C virus (HIV/HCV) coinfection occurs when a patient is simultaneously infected with both human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV), which is common today in certain popul...
Bayes Theorem Hepacivirus Hepatitis C HIV-1 Molecular Conformation Quantitative Structure-Activity Relationship Databases, Pharmaceutical Polypharmacology Anti-HIV Agents Humans Antiviral Agents Machine Learning Protein Binding Algorithms Models, Molecular Drug Discovery Molecular Structure HIV Infections
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Intelligent Network DisRuption Analysis (INDRA): A targeted strategy for efficient interruption of hepatitis C transmissions.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases May 31, 2018
Hepatitis C virus (HCV) infection is a global public health problem. The implementation of public health interventions (PHI) to control HCV infection could effectively interrupt HCV transmission. PHI targeting high-risk populations, e.g., people who ...
Indiana HIV Infections Incidence Coinfection HIV Hepacivirus Hepatitis C Contact Tracing Substance Abuse, Intravenous Universal Precautions Humans Neural Networks, Computer
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HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer.

Breast cancer (Tokyo, Japan) Dec 28, 2017
BACKGROUND: Hepatitis C virus (HCV) has the lymphotropic feature that is supposed to be the reason of related extrahepatic manifestation. HCV viral oncoproteins may participate in the regulation of some gene expression that has been implicated in tum...
Neoplasm Grading Fibronectins Hepacivirus Hepatitis C Viral Nonstructural Proteins Gene Expression Regulation, Neoplastic Humans Enzyme-Linked Immunosorbent Assay Female Carcinogenesis Aged Mucin-1 Egypt Adult Hepatitis C Antibodies Neoplasm Staging Breast Neoplasms Middle Aged Disease Progression Incidence
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UPLC-MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 12, 2017
Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication rates in HCV mono- and HIV/HCV co-infected patients. In this scenery, availability of Therapeutic D...
Carbamates Antiviral Agents Pyrrolidines Imidazoles Limit of Detection Humans Sofosbuvir Reproducibility of Results Coinfection Tandem Mass Spectrometry HIV Infections Chromatography, High Pressure Liquid Hepatitis C Linear Models Valine
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