AIMC Topic: Hippocampus
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Predicting individual responses to the electroconvulsive therapy with hippocampal subfield volumes in major depression disorder.
Scientific reports
Apr 3, 2018
Electroconvulsive therapy (ECT) is one of the most effective treatments for major depression disorder (MDD). ECT can induce neurogenesis and synaptogenesis in hippocampus, which contains distinct subfields, e.g., the cornu ammonis (CA) subfields, a g...
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters.
Nature chemical biology
Feb 26, 2018
We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing prote...
Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats.
PloS one
Feb 12, 2018
Hippocampal theta oscillations have been implicated in working memory and attentional process, which might be useful for the brain-machine interface (BMI). To further elucidate the properties of the hippocampal theta oscillations that can be used in ...
Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus.
NeuroImage
Dec 27, 2017
The hippocampus is a highly stress susceptible structure and hippocampal abnormalities have been reported in a host of psychiatric disorders including major depression and post-traumatic stress disorder (PTSD). The hippocampus appears to be particula...
Learning non-linear patch embeddings with neural networks for label fusion.
Medical image analysis
Dec 2, 2017
In brain structural segmentation, multi-atlas strategies are increasingly being used over single-atlas strategies because of their ability to fit a wider anatomical variability. Patch-based label fusion (PBLF) is a type of such multi-atlas approaches...
Dendrites, deep learning, and sequences in the hippocampus.
Hippocampus
Oct 30, 2017
The hippocampus places us both in time and space. It does so over remarkably large spans: milliseconds to years, and centimeters to kilometers. This works for sensory representations, for memory, and for behavioral context. How does it fit in such wi...
Learning-based deformable registration for infant MRI by integrating random forest with auto-context model.
Medical physics
Oct 19, 2017
PURPOSE: Accurately analyzing the rapid structural evolution of human brain in the first year of life is a key step in early brain development studies, which requires accurate deformable image registration. However, due to (a) dynamic appearance and ...
Dorsoventral and Proximodistal Hippocampal Processing Account for the Influences of Sleep and Context on Memory (Re)consolidation: A Connectionist Model.
Computational intelligence and neuroscience
Jul 3, 2017
The context in which learning occurs is sufficient to reconsolidate stored memories and neuronal reactivation may be crucial to memory consolidation during sleep. The mechanisms of context-dependent and sleep-dependent memory (re)consolidation are un...
Feature selective temporal prediction of Alzheimer's disease progression using hippocampus surface morphometry.
Brain and behavior
Jun 9, 2017
INTRODUCTION: Prediction of Alzheimer's disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end, we combine a predictive multi-task m...
Dendritic spine classification using shape and appearance features based on two-photon microscopy.
Journal of neuroscience methods
Dec 18, 2016
BACKGROUND: Neuronal morphology and function are highly coupled. In particular, dendritic spine morphology is strongly governed by the incoming neuronal activity. The first step towards understanding the structure-function relationships is to classif...
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