AIMC Topic: Human Umbilical Vein Endothelial Cells

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Integrating single-cell analysis and machine learning to identify COPD hub genes and explore the intervention mechanism of effective component compatibility of Bufei Yishen formula III.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a prevalent condition that poses a major threat to public health. Endothelial cells play a critical role in COPD pathogenesis. Recent evidence suggests that the effective...

Effect of Cell-Cell Interaction on Single-Cell Behavior Revealed by a Deep Learning-Aided High-Throughput Addressable Single-Cell Coculture System.

Analytical chemistry
Cell-cell interactions are crucial for understanding various physiological and pathological processes, yet conventional population-level methods fail to disclose the heterogeneity at a single-cell resolution. Single-cell coculture systems that isolat...

Changes of plasma Rap1A levels in patients with in-stent restenosis after percutaneous coronary intervention and the underlying mechanisms.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
OBJECTIVES: Percutaneous coronary intervention (PCI) is one of the most important treatments for coronary artery disease (CAD). However, in-stent restenosis (ISR) after PCI is a serious complication without effective measures for prevention and treat...

Predicting enhancer-promoter interactions by deep learning and matching heuristic.

Briefings in bioinformatics
Enhancer-promoter interactions (EPIs) play an important role in transcriptional regulation. Recently, machine learning-based methods have been widely used in the genome-scale identification of EPIs due to their promising predictive performance. In th...

Shape anisotropy-governed locomotion of surface microrollers on vessel-like microtopographies against physiological flows.

Proceedings of the National Academy of Sciences of the United States of America
Surface microrollers are promising microrobotic systems for controlled navigation in the circulatory system thanks to their fast speeds and decreased flow velocities at the vessel walls. While surface propulsion on the vessel walls helps minimize the...

[Role of high mobility group protein B1 in 
IL-1α-induced endothelial cell senescence].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
 Methods: HUVECs were randomly divided into a control group, a IL-1α group...

[Ulinastatin attenuates hyper-permeability of vascular endothelialium cells induced by serum from patients with sepsis].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Objective To study the effect of ulinastatin (UTI) on the hyper-permeability of human umbilical vein endothelial cell induced by the serum from patients with severe sepsis. Methods The serum level of tumor necrosis factor α (TNF-α) was examined by EL...

Marsdeniae tenacissimae extract (MTE) suppresses cell proliferation by attenuating VEGF/VEGFR2 interactions and promotes apoptosis through regulating PKC pathway in human umbilical vein endothelial cells.

Chinese journal of natural medicines
Marsdeniae tenacissimae extract (MTE), commonly known as Xiao-Ai-Ping in China, is a traditional Chinese herb medicine capable of inhibiting proliferation and metastasis and boosting apoptosis in various cancer cells. However, little is known about t...

[Biologic effects of different concentrations of putrescine on human umbilical vein endothelial cells].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
OBJECTIVE: To explore the effects of different concentrations of putrescine on proliferation, migration, and apoptosis of human umbilical vein endothelial cells (HUVECs).