AIMC Topic: Humans

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Population norms for the EQ-5D-5L for Hungary: comparison of online surveys and computer assisted personal interviews.

The European journal of health economics : HEPAC : health economics in prevention and care
BACKGROUND AND OBJECTIVES: The aims of this study were to provide population norms for EQ-5D-5L in Hungary and investigate the differences in EQ-5D-5L normative data by survey mode, i.e. online surveys and computer assisted personal interviews (CAPI)...

Measuring kidney stone volume - practical considerations and current evidence from the EAU endourology section.

Current opinion in urology
PURPOSE OF REVIEW: This narrative review provides an overview of the use, differences, and clinical impact of current methods for kidney stone volume assessment.

Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.

Acta pharmacologica Sinica
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance of MM cells, identification of novel genes could provide valuable insights for...

Identification of crucial genes for polycystic ovary syndrome and atherosclerosis through comprehensive bioinformatics analysis and machine learning.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
OBJECTIVE: To identify potential biomarkers in patients with polycystic ovary syndrome (PCOS) and atherosclerosis, and to explore the common pathologic mechanisms between these two diseases in response to the increased risk of cardiovascular diseases...

Food-derived DPP4 inhibitors: Drug discovery based on high-throughput virtual screening and deep learning.

Food chemistry
Dipeptidyl peptidase-4 (DPP-4) is a critical target for the treatment of type 2 diabetes. This study outlines the development of six compounds derived from food sources and modified to create promising candidates for the treatment of diabetes. These ...

Self-triggered neural tracking control for discrete-time nonlinear systems via adaptive critic learning.

Neural networks : the official journal of the International Neural Network Society
In this paper, a novel self-triggered optimal tracking control method is developed based on the online action-critic technique for discrete-time nonlinear systems. First, an augmented plant is constructed by integrating the system state with the refe...

Effectiveness of Transformer-Based Large Language Models in Identifying Adverse Drug Reaction Relations from Unstructured Discharge Summaries in Singapore.

Drug safety
INTRODUCTION: Transformer-based large language models (LLMs) have transformed the field of natural language processing and led to significant advancements in various text processing tasks. However, the applicability of these LLMs in identifying relat...

Neurobiologically interpretable causal connectome for predicting young adult depression: A graph neural network study.

Journal of affective disorders
BACKGROUND: There is a surprising lack of neuroimaging studies of depression that not only identify the whole brain causal connectivity features but also explore whether these features have neurobiological correlates.

Large-scale benchmarking and boosting transfer learning for medical image analysis.

Medical image analysis
Transfer learning, particularly fine-tuning models pretrained on photographic images to medical images, has proven indispensable for medical image analysis. There are numerous models with distinct architectures pretrained on various datasets using di...

Hyperfusion: A hypernetwork approach to multimodal integration of tabular and medical imaging data for predictive modeling.

Medical image analysis
The integration of diverse clinical modalities such as medical imaging and the tabular data extracted from patients' Electronic Health Records (EHRs) is a crucial aspect of modern healthcare. Integrative analysis of multiple sources can provide a com...