A comprehensive understanding of protein corona (PC) composition is critical for engineering nanoparticles (NPs) with optimal safety and therapeutic performance, because the PC governs NP pharmacokinetics, biodistribution, and cellular interactions. ...
Outbreaks of SARS-CoV-2, first investigated as an unknown pathogen, have reflected the severe threat that pathogen X poses to public health and social security. Early and precise diagnosis and classification of infectious respiratory diseases with si...
Forensic body fluid identification is crucial for reconstructing crime scene events. While DNA analysis provides individualization, it lacks information about the fluid's origin. We developed and evaluated three complementary proteomic approaches usi...
The rapid development of internet of things, big data, and artificial intelligence is propelling sports science into a data-driven era, demanding real-time, multidimensional athletic performance monitoring. Triboelectric nanogenerators (TENGs) have d...
Evolutionary instability is a persistent challenge in synthetic biology, often leading to the loss of heterologous gene expression over time. Here, we present STABLES, a gene fusion strategy that links a gene of interest (GOI) to an essential endogen...
BACKGROUND: Digital health history devices represent a promising wave of digital tools with the potential to enhance the quality and efficiency of medical consultations. They achieve this by providing physicians with standardized, high-quality patien...
OBJECTIVE: The aim of the study was to compare the diagnostic quality of deep learning (DL) reconstructed balanced steady-state free precession (bSSFP) single-shot (SSH) cine images with standard, multishot (also: segmented) bSSFP cine (standard cine...
OBJECTIVES: Respiratory motion poses a significant challenge for clinical workflows in diagnostic imaging and radiation therapy. Many technologies such as motion artifact reduction and tumor tracking have been developed to compensate for its effect. ...
Determination of cardiac output (CO) is essential to the clinical management of cardiovascular compromise. However, the invasiveness, procedural risks, and reliance on specialized infrastructure limit accessibility and scalability of standard-of-care...
European journal of medicinal chemistry
Sep 30, 2025
Delivering small molecules to the brain and central nervous system (CNS) is greatly hindered by the restrictive blood-brain barrier (BBB), which selectively permits essential molecules while excluding toxic molecules. This selective permeability feat...
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