Humans

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Computational design of thermostabilizing point mutations for G protein-coupled receptors.

eLife Jun 21, 2018
Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational ap...
Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Point Mutation Serotonin 5-HT2 Receptor Agonists Sequence Alignment Sequence Homology, Amino Acid Protein Interaction Domains and Motifs Serotonin 5-HT2 Receptor Antagonists Amino Acid Sequence Protein Stability Receptor, Serotonin, 5-HT2C Protein Engineering Thermodynamics Crystallography, X-Ray Binding Sites Models, Molecular Gene Expression Kinetics Machine Learning Animals Protein Binding Humans
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Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy.

BMC bioinformatics Jun 21, 2018
BACKGROUND: Spastic cerebral palsy (CP) is a leading cause of physical disability. Most people with spastic CP are born with it, but early diagnosis is challenging, and no current biomarker platform readily identifies affected individuals. The aim of...
Biomarkers Female Male Case-Control Studies Humans Machine Learning Cerebral Palsy Sequence Analysis, DNA Pattern Recognition, Automated Adolescent DNA Methylation Genetic Predisposition to Disease Genome, Human Epigenomics
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Comparison of Transferred Deep Neural Networks in Ultrasonic Breast Masses Discrimination.

BioMed research international Jun 21, 2018
This research aims to address the problem of discriminating benign cysts from malignant masses in breast ultrasound (BUS) images based on Convolutional Neural Networks (CNNs). The biopsy-proven benchmarking dataset was built from 1422 patient cases c...
Diagnosis, Computer-Assisted Retrospective Studies Humans Breast Diseases Biopsy Neural Networks, Computer Female Cysts Breast Neoplasms Machine Learning
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Gastric Pathology Image Classification Using Stepwise Fine-Tuning for Deep Neural Networks.

Journal of healthcare engineering Jun 21, 2018
Deep learning using convolutional neural networks (CNNs) is a distinguished tool for many image classification tasks. Due to its outstanding robustness and generalization, it is also expected to play a key role to facilitate advanced computer-aided d...
Stomach Stomach Neoplasms Neural Networks, Computer Image Interpretation, Computer-Assisted Humans Histocytochemistry Algorithms
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An Intelligent Parkinson's Disease Diagnostic System Based on a Chaotic Bacterial Foraging Optimization Enhanced Fuzzy KNN Approach.

Computational and mathematical methods in medicine Jun 21, 2018
Parkinson's disease (PD) is a common neurodegenerative disease, which has attracted more and more attention. Many artificial intelligence methods have been used for the diagnosis of PD. In this study, an enhanced fuzzy -nearest neighbor (FKNN) method...
Cluster Analysis Humans Parkinson Disease Artificial Intelligence Algorithms Male Female Middle Aged Aged Support Vector Machine Aged, 80 and over Fuzzy Logic
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Road screening and distribution route multi-objective robust optimization for hazardous materials based on neural network and genetic algorithm.

PloS one Jun 21, 2018
Route optimization of hazardous materials transportation is one of the basic steps in ensuring the safety of hazardous materials transportation. The optimization scheme may be a security risk if road screening is not completed before the distribution...
Transportation Neural Networks, Computer Algorithms Hazardous Substances Humans
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A self-organizing short-term dynamical memory network.

Neural networks : the official journal of the International Neural Network Society Jun 20, 2018
Working memory requires information about external stimuli to be represented in the brain even after those stimuli go away. This information is encoded in the activities of neurons, and neural activities change over timescales of tens of milliseconds...
Humans Neural Networks, Computer Models, Neurological Memory, Short-Term Brain Neuronal Plasticity Neurons Synapses Nerve Net
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A Novel Soft Pneumatic Artificial Muscle with High-Contraction Ratio.

Soft robotics Jun 20, 2018
There is a growing interest in soft actuators for human-friendly robotic applications. However, it is very challenging for conventional soft actuators to achieve both a large working distance and high force. To address this problem, we present a high...
Muscle Contraction Humans Models, Theoretical Equipment Design Biomimetics Muscle, Skeletal Robotics
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Advances in the computational and molecular understanding of the prostate cancer cell nucleus.

Journal of cellular biochemistry Jun 20, 2018
Nuclear alterations are a hallmark of many types of cancers, including prostate cancer (PCa). Recent evidence shows that subvisual changes, ones that may not be visually perceptible to a pathologist, to the nucleus and its ultrastructural components ...
Prognosis Tumor Microenvironment Male Epigenesis, Genetic Humans Machine Learning Genomic Instability Cell Nucleus Shape Chromatin Cell Nucleus Size Prostatic Neoplasms Cell Transformation, Neoplastic Image Interpretation, Computer-Assisted
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Generalizable and Scalable Visualization of Single-Cell Data Using Neural Networks.

Cell systems Jun 20, 2018
Visualization algorithms are fundamental tools for interpreting single-cell data. However, standard methods, such as t-stochastic neighbor embedding (t-SNE), are not scalable to datasets with millions of cells and the resulting visualizations cannot ...
Single-Cell Analysis Genomics Sequence Analysis, RNA Computer Graphics Cluster Analysis Humans Stochastic Processes Neural Networks, Computer Software Algorithms
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