AIMC Topic: Humans

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Effect of visceral fat on onset of metabolic syndrome.

Scientific reports
This study analysed the effects of visceral fat on metabolic syndrome (MetS) and developed an algorithm to predict its onset using health examination data from the Iwaki Health Promotion Project in Japan. The dataset included 213 cases of MetS onset ...

Upper limb human-exoskeleton system motion state classification based on semg: application of CNN-BiLSTM-attention model.

Scientific reports
This study aims to classify five typical motion states of the human upper limb based on surface electromyography signals, thereby supporting the real-time control system of an assistive upper limb exoskeleton. We propose a deep learning model combini...

Pixel super-resolved virtual staining of label-free tissue using diffusion models.

Nature communications
Virtual staining of tissue offers a powerful tool for transforming label-free microscopy images of unstained tissue into equivalents of histochemically stained samples. This study presents a diffusion model-based pixel super-resolution virtual staini...

A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy.

Nature communications
Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and d...

Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment.

Nature communications
Infective endocarditis, a life-threatening condition, poses challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we performed proteomic profiling of plasma an...

Assessing the performance of a point-of-need diagnostic algorithm in rapid detection of peripheral lymph node tuberculosis (Mobile-TB-Lab): a diagnostic evaluation study protocol.

BMJ open
INTRODUCTION: Early and accurate diagnosis of tuberculosis (TB) is central to ensuring the proper treatment and curbing the transmission of the disease. Despite the significant burden, the diagnosis of peripheral lymph node(LN)TB, the most prevalent ...

Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors.

Journal for immunotherapy of cancer
BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform...

The Role of Digital Health Equity Audits in Preventing Harmful Infodemiology.

JMIR infodemiology
BACKGROUND: Health disparities persist and are influenced by digital transformation. Although digital tools offer opportunities, they can also exacerbate existing inequalities, a problem amplified by the COVID-19 pandemic and the related infodemic. H...

Experience of Cardiovascular and Cerebrovascular Disease Surgery Patients: Sentiment Analysis Using the Korean Bidirectional Encoder Representations from Transformers (KoBERT) Model.

JMIR medical informatics
BACKGROUND: Cardiovascular and cerebrovascular diseases significantly contribute to global mortality and disability. The shift to outpatient postoperative care, accelerated by the COVID-19 pandemic, emphasizes the need for effective management of pos...

Requirement Analysis for Data-Driven Electroencephalography Seizure Monitoring Software to Enhance Quality and Decision Making in Digital Care Pathways for Epilepsy: A Feasibility Study from the Perspectives of Health Care Professionals.

JMIR human factors
BACKGROUND: Abnormal brain activity is the source of epileptic seizures, which can present a variety of symptoms and influence patients' quality of life. Therefore, it is critical to track epileptic seizures, diagnose them, and provide potential ther...