BACKGROUND: Differential expression (DE) analysis of transcriptomic data enables genome-wide analysis of gene expression changes associated with biological conditions of interest. Such analysis often provides a wide list of genes that are differentia...
BACKGROUND: Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy...
BACKGROUND: A major challenge in biodiversity science is to understand the factors contributing to the variability of species richness -the number of different species in a community or region - among comparable taxonomic lineages. Multiple biotic an...
Genomics, proteomics & bioinformatics
Aug 28, 2020
As an important protein acylation modification, lysine succinylation (Ksucc) is involved in diverse biological processes, and participates in human tumorigenesis. Here, we collected 26,243 non-redundant known Ksucc sites from 13 species as the benchm...
Accumulating evidence suggests M2 macrophages contribute to tissue reparation and limit inflammation in multiple sclerosis (MS). However, most studies have focused on murine models without substantial support through human MS observations. The presen...
In the age of machine learning, building programs that take advantage of the speed and specificity of algorithm development can greatly aid efforts to quantify and interpret changes in animal behavior in response to abiotic environmental factors, lik...
Neural networks : the official journal of the International Neural Network Society
Aug 27, 2020
Multi-view graph embedding is aimed at learning low-dimensional representations of nodes that capture various relationships in a multi-view network, where each view represents a type of relationship among nodes. Multitudes of existing graph embedding...
Journal of the American Medical Directors Association
Aug 27, 2020
OBJECTIVE: Inform coronavirus disease 2019 (COVID-19) infection prevention measures by identifying and assessing risk and possible vectors of infection in nursing homes (NHs) using a machine-learning approach.
The Lancet. Child & adolescent health
Aug 27, 2020
BACKGROUND: Despite the availability of continuous conventional electroencephalography (cEEG), accurate diagnosis of neonatal seizures is challenging in clinical practice. Algorithms for decision support in the recognition of neonatal seizures could ...
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